Recurrent AA Amyloidosis After Renal Transplantation: Effects on Allograft Survival
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Istanbul University
- Enrollment
- 54
- Locations
- 4
- Primary Endpoint
- Allograft survival
Overview
Brief Summary
End-stage renal disease related to AA amyloidosis is well characterized but there is limited data concerning patient and graft outcomes after renal transplantation. The aim of this study is to evaluate the clinical features of, and risk factors for recurrent AA amyloidosis, as well as the effects of these factors on the ultimate outcome of renal allografts.
Detailed Description
AA amyloidosis is a rare but serious complication of several chronic inflammatory diseases including recurrent hereditary periodic fever syndromes. Although end-stage renal disease related to AA amyloidosis is well characterized, there is limited data concerning patient and graft outcomes after renal transplantation, with most of the findings reported from small series. Recurrence of amyloidosis in the renal allograft might be underdiagnosed, assessing graft and patient outcomes in larger study groups will bring better understanding and new strategies in daily practice.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Renal transplantation recipients whose primary renal disease is AA amyloidosis; patients with allograft biopsy-confirmed AA amyloidosis (for study group) and patients with no clinical or laboratory signs of recurrence in the renal allograft (for control group 1)
- •Renal transplantation recipients whose primary diseases are other than AA amyloidosis (for control group 2)
Exclusion Criteria
- •Patients who are unwilling or unable to consent
Outcomes
Primary Outcomes
Allograft survival
Time Frame: 1 - 5 years
Secondary Outcomes
- Allograft rejection(1 - 5 years)
Investigators
Yasar Caliskan
Associate Professor of Medicine
Istanbul University