Comparison of cardiovascular structure and function in physical active subjects with or without myocardial infarctio

Recruiting

Conditions: heart attack
Myocardial infarction
10028593

Registration Number: NL-OMON37343

Lead Sponsor: CtrtP Scientific Writing and Conulting

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Informed consent
Men and women aged 40-70 years
For active groups, regular physical active (i.e. aerobic exercise such as running >=3 times a week), for at least 20 years
For MI groups, myocardial infarction within the past 5 years

Exclusion Criteria

Smokers
Type I or II diabetes mellitus
Other diseases that interfere with exercise testing
For subject in non-MI groups:
- hypercholesterolemia
- hypertension

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Vascular structure and function (conduit artery endothelial function, conduit<br /><br>artery diameter, blood flow, IMT, conduit and resistance artery structure, peak<br /><br>hypereamic blood flow, exercise-induced vasodilation)<br /><br><br /><br>Plaque vulnerability by ultrasoiund and serum biomarkers (hs-CRP, SAA, IL-6,<br /><br>MMP-9, MMP-2, TIMP-1, TIMP-2)<br /><br><br /><br>Cardiac structure and function (cardiac mass and dimensions, systolic and<br /><br>diastolic function parameters, left and right ventricle strain rate) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives include groups comparisons of physical fitness and<br /><br>traditional risk factors, i.e. cholesterol, lipid profile, HbA1C, insulin<br /><br>sensitivity, blood pressure, and waist circumference.<br /><br><br /><br>Two extra blood samples will be drawn and stored for future analyses (if no<br /><br>objection participant), in case relevant CVD genetic candidates become<br /><br>available. </p><br>