Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl

Phase 4

• Conditions: Hypokalemia

• Registration Number: NCT02721095
• Lead Sponsor: Phramongkutklao College of Medicine and Hospital

Brief Summary

evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia

Detailed Description

Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia.

Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2015-05-25
• Study First Submitted QC: 2016-03-22
• Study First Posted: 2016-03-28
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-01
• Last Update Posted: 2016-05-03
• Primary Completion: 2016-07
• Study Completion: 2016-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Serum K+ 2.5-3.49 mmol/L
• No life threatening condition from hypokalemia

Exclusion Criteria

• Pregnancy
• Volume overload, heart failure
• Hypotension
• Acute kidney injury
• Dysnatremia
• K+ shift
• Salt wasting nephropathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Number of participants with normal serum K as assessed by serum electrolyte	24 hours

Trial Locations

Locations (1)

Phramonkutklao Hospital; 🇹🇭 Bangkok, Thailand