Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Psychosis

Not Applicable

Completed

• Conditions: Psychosis
• Interventions: Device: tDCS

• Registration Number: NCT02085421
• Lead Sponsor: University of Minnesota

Brief Summary

The proposed pilot study is a randomized controlled study to assess effectiveness of transcranial direct current stimulation (tDCS) to enhance cognitive remediation therapy in patients with psychotic disorders. tDCS. Patients will be randomized into two arms: active tDCS vs. sham tDCS. The active tDCS will be applied at a current of 1-2 mA (milliamperes) via two saline soaked electrode sponges (3 cm x 4.5 cm) applied to the side of the head. The investigators hypothesis is that the use of tDCS will enhance the improvement seen with cognitive remediation therapy.

Detailed Description

The proposed pilot study is a randomized controlled study to assess effectiveness of tDCS to enhance cognitive remediation therapy in patients with psychotic disorders. All patients will participate in cognitive remediation therapy (CRT). After initial consent form has been signed, all participants will undergo various neurocognitive and psychological assessments including the Brief Assessment of Cognition in Schizophrenia (BACS), an EEG, and several other tasks/assessments. Participants will then complete 2-4 CRT sessions per week, each lasting approximately one hour, for a total of 10 sessions. The CRT will use a commercially available PositScience software package. Each CRT session involves an in-session assessment of skill acquisition, as collected by commercially available CRT software.

Patients will be randomized into two arms: active tDCS vs. sham tDCS. The tDCS will be applied at a current of 1-2mA via two saline soaked electrode sponges (3 cm x 4.5 cm) each CRT session. The anode will be placed over left DLPFC (dorsolateral prefrontal cortex) at F3, according to the 10-20 international system for EEG electrode placement. The cathode will be placed over the contralateral supraorbital area (Fp2). This placement is consistent with previous protocols targeting working memory. Both active and sham conditions will have identical electrode placement.

After electrodes have been placed, the participants will be instructed to log into CRT software using a unique patient identifier. Once logged in to CRT software they will be instructed to begin the session.

The tDCS will be applied at a current of 1-2mA via two saline soaked electrode sponges (3 cm x 4.5 cm) for the first 20 minutes of each CRT session in the active condition. In the sham condition, tDCS will be ramped up to 1-2 mA via two saline soaked electrode sponges (3 cm x 4.5 cm) over the first 30 seconds of each CRT session and then turned off.

Participants will complete the hour long CRT session. The software program instructs the patient when the end of the session has been reached.

At the completion of the 10 sessions of CRT, both active and sham tDCS patients will repeat the the same assessments from the beginning, including the BACS, another EEG, and several other tasks/assessments. Patients will also be asked to return for a 1-month follow-up where most of the same tasks/assessments are completed.

The consent and baseline assessments take about 8 hours in total and can be split up into 2-4 appointments. Each of the 10 training sessions lasts approximately 1 hour for a total of 10 hours of training. The post-training assessments take about 6 hours and can be split up into 2-3 appointments. The 1-month follow-up takes approxmately 3.5 hours and can be completed in 1-2 appointments. The total time commitment for this study is approximately 28-32 hours.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-03-06
• Study First Submitted QC: 2014-03-10
• Study First Posted: 2014-03-12
• Study Start: 2019-03-14
• Status Verified: 2023-02
• Primary Completion: 2023-02-09
• Study Completion: 2023-02-09
• Last Update Submitted: 2023-02-12
• Last Update Posted: 2023-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. Meet diagnostic criteria for schizophrenia or schizoaffective disorder
2. Are age 18-64
3. Fluent in written and spoken English
4. Have an outpatient status of at least 1 month prior to participation
5. Has been on a stable dose of psychiatric medication for at least one month prior to participation

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Exclusion Criteria

1. History of seizures or epilepsy
2. Metallic cranial plates, screws, or implanted devices
3. History of craniotomy
4. History of stroke
5. History of eczema on scalp
6. Pre-existing sores or lesions at sites of tDCS electrode placement
7. Non removable facial piercings
8. Current or possibility of current pregnancy
9. Has received a clinically meaningful dose of a targeted cognitive training intervention in the last 12 months

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Active tDCS	tDCS	The active tDCS will be applied at a current of 1-2mA via two saline soaked electrode sponges (3 cm x 4.5 cm) for the first 20 minutes of each CRT session in the active condition.
Sham tDCS	tDCS	In the sham condition, tDCS will be ramped up to 1-2 mA via two saline soaked electrode sponges (3 cm x 4.5 cm) over the first 30 seconds of each CRT session and then turned off.

Primary Outcome Measures

Name	Time	Method
Change in N-Back from Baseline to Post-Training	Baseline, 3-5 weeks	N-back testing is a performance task used to assess working memory. N-back testing will be run using software package E Prime (Psychology Software Tools).
Change in Brief Assessment of Cognition in Schizophrenia (BACS) from Baseline to Post-Training	Baseline, 3-5 weeks
Change in VRFCAT from Baseline to Post-Training	Baseline, 3-5 weeks	This is a performance-based functional capacity measure.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States