Human Papillomavirus Infection and Related Anal Lesions in HIV-positive Men Who Have Sex With Men
- Conditions
- Hiv Infection
- Registration Number
- NCT02287961
- Lead Sponsor
- ANRS, Emerging Infectious Diseases
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Men who have sex with men<br><br> - At least 35 years old<br><br> - HIV-positive (documented search of HIV infection, with HIV status determined<br> according to HAS algorithm)<br><br> - Signed informed consent<br><br> - Affiliated to or beneficiary of French social security<br><br> - All severity criteria and evolution of HIV disease are accepted (including AIDS<br> stage and co-infections)<br><br>Exclusion Criteria:<br><br> - Contraindication to biopsy<br><br> - History of anal cancer or pelvic radiotherapy<br><br> - AIN2/3 treated during previous year<br><br> - Current anticancer chemotherapy or within 24 months before inclusion<br><br> - Difficulty in evaluation (anus reshaped and/or scarred)<br><br> - Individual placed under judicial protection<br><br> - Foreseen absence which may hamper participation; insufficient motivation; associated<br> pathology with priority for care
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of high-grade anal lesions by high resolution anoscopy;Evaluation of anal HPV infection by DNA, RNA and protein detection;Quantification of spontaneous regression of high-grade anal lesions
- Secondary Outcome Measures
Name Time Method Evaluation of anal HPV infection by DNA, RNA and protein detection;Evaluation of anal HPV infection by DNA, RNA and protein detection;Evaluation of anal HPV infection by DNA, RNA and protein detection;Evaluation of anal HPV infection by DNA, RNA and protein detection