The long-term effect of full-mouth tooth extraction and subsequent implant placement on the oral microflora
- Conditions
- edentulismtoothless10004018
- Registration Number
- NL-OMON45370
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
1) The patient is >= 18 years of age;
2) The patient has a hopeless residual dentition of at least 4 teeth for which extraction of all teeth is the only remaining treatment modality.
3) The patient is diagnosed with mild or severe periodontitis (2 approximal sites with at least 2 mm of clinical attachment loss or probing pocket depth of at least 5 mm).
4) The patient is capable of understanding and giving informed consent.
1) Medical and general contraindications for the surgical procedures;
2) A history of local radiotherapy to the head and neck region;
3) Chemotherapy in the previous 6 months;
4) Systemic or local use of antibiotics in the oral cavity during the last 3 months;
5) Use of anti-septic / antimicrobial therapies (including mouthrinses) in the oral cavity during the last 4 weeks;
6) Patients with dental implants remaining in the oral cavity after full-mouth tooth extraction.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Changes in relative abundance of bacterial species over time as analysed by 16S<br /><br>next generation sequencing technique.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>