Use of Bramhi as a mouth rinse for gum disease

Phase 3

Not yet recruiting

Conditions: Other specified diseases of jaws,

Registration Number: CTRI/2024/10/075791

Lead Sponsor: Niharika KG

Brief Summary: Oral microbiome plays a major role in the initiation of gingival pathology. Dental biofilm comprises of diverse microbial community which are embedded in tooth surfaces as dental plaque. Elimination of plaque has been the hallmark of prevention of the gingival and periodontal infections.Harald Loe and colleagues demonstrated the direct relationship between plaque levels and the development of gingivitis. Plaque removal can reverse the inflammatory changes.Chemical plaque control adjunctive to mechanical plaque control is shown to be more effective.

In our study, we aimed to introduce a newer plaque control herbal mouthwash. Herbal medicinehave been applied in dentistry for a long time to inhibit micro organisms, reduce inflammation, soothe irritation, and relieve pain.

*Bacopa monnieri* has been used as a reputed drug in theIndian traditional ayurvedic system for centuries. The medicinal herb with important phytopharmaceuticals has been popularly known as "Brahmi",is a perennial creeping plant found throughout India in wet, damp and marshy areas.

In recent years, *B. monnieri* has been extensively studied for its bioactive constituents,responsible for memory enhancing effect, and its other diverse useful effects as it possesses many pharmacological activities such as antioxidant, anti-inflammatory, gastrointestinal, anti-anxiety, anti-depression, anti-stress, antimicrobial, properties. *Bacopa monnieri* has been used in medical field in the treatment ofcognitive functions,Alzheimerâ€™s disease, depression, enhance memory development, learning and concentration and to provide relief to patients with anxiety or epileptic disorders.

With this background in our present study, we have tried using *Bacopa monnieri*mouthwash in gingivitis patients. Years of documented research have established chlorhexidine mouthwash is stable, effective in preventing and controlling plaque formation and inhibiting gingivitis. Hence in the current study we are comparing the anti-inflammatory effect of *Bacopa monnieri* mouthwash with chlorhexidine .

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 76

Inclusion Criteria

a.Subjects who are systemically healthy b.Subjects who had moderate to severe gingivitis (Loe and Sillness, 1963) c.Subjects 18-55years male and females.

Exclusion Criteria

a.Subjects who had undergone periodontal treatment for the past 6months b.Subjects who are already using mouthwash c.Subjects with gross oral pathology like cysts and tumors d.Subjects who are on anti biotic and anti-inflammatory medications for past 6 months e.Smokers and tobacco chewers f.Pregnant and lactating women g.subjects allergic to herbal products.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bacopa monnieri mouthwash can be used as a anti inflammatory mouthwash	14th day and 21st day

Secondary Outcome Measures

Name	Time	Method
Bacopa monnieri can be used alternative to the routine mouthwashes.	IL-6 levels at 21st day

Trial Locations

Locations (1): SDM College of dental sciences and hospital
🇮🇳
Dharwad, KARNATAKA, India
SDM College of dental sciences and hospital
🇮🇳Dharwad, KARNATAKA, India
Dr Niharika K G
Principal investigator
6360359896
niharikakubsad@gmail.com