Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.
Completed
- Conditions
- PharmacokineticsCritical Illness
- Registration Number
- NCT03438981
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset
- Detailed Description
First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid.
Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.
Finally in a small subset of ECMO patients PK exposure will be explored.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Pneumonia
- Admitted to an ICU ward
- Treated with ceftriaxone
Exclusion Criteria
- Pregnancy
- DNR code 2-3
- Renal replacement therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Risk factors for target non attainment on day of sampling risk factors will be assessed by comparing patients who attain target vs. those who don't
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UZLeuven
🇧🇪Leuven, Belgium