Comparison of the effect of intraoperative intravenous lidocaine and dexmedetomidine infusions on post-operative pain and recovery profile in spine surgeries
Phase 2
- Conditions
- Health Condition 1: - Health Condition 2: G959- Disease of spinal cord, unspecified
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a.
Patients scheduled for elective spine surgeries (one or two vertebrae levels) under General anesthesia
1.Adult patients aged 18-70years belonging to either sex.
2.American society of Anesthesiologists (ASA) physical status 1-2
Exclusion Criteria
b.
1.Allergy to any of the drugs used in the study i.e., lidocaine and dexmedetomidine.
2.Patients having impaired hepatic or renal function or ischemic heart disease.
3.Patients with conduction blocks or arrhythmias.
4.Patients with psychiatric illness and seizure disorder.
5.Patients who are on opioid supplements for pain management within two weeks of surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of 24 hours post-operative morphine consumption between the groups using patient-controlled analgesiaTimepoint: Postoperatively all patients will have access to PCA pump for 24 hours to receive a bolus of 1 mg morphine with a lock-out interval of 15 minutes without background infusion.
- Secondary Outcome Measures
Name Time Method Comparison of <br/ ><br>1 Intraoperative fentanyl requirement between the groups <br/ ><br>2 Hemodynamic parameters MAP & HR between groups <br/ ><br>3 Time of emergence between groups <br/ ><br>4 Pain at postoperative periods of 1 6 12 24 48 hours using NRS pain scale between groups at rest & during movement <br/ ><br>5 Opioid related side effects postoperative nausea & vomiting pruritus sedation using Richmond Agitation Sedation scale <br/ ><br>6 Recovery characteristics between groups using Quality of Recovery 15 QoR15 score at the end of 48 hours in the postoperative period <br/ ><br>Timepoint: 1 6 12 24 48 hours pain score in postoperative period