ACTRN12612000710820
Not yet recruiting
Phase 4
ovel Interventions in Heart Failure with Preserved Ejection Fraction -a single centre, randomised double blinded placebo cross-over pilot study using IVABRADINE, to assess the effect on 6 minute walk test, peak oxygen consumption and New York heart association Class of symptoms, from the Flinders Clinical Research group, Flinders University.
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Heart Failure with Preserved Ejection Fraction
- Sponsor
- South Australian Health and Medical Research Institute
- Enrollment
- 20
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age greater than or equal to 18 years
- •HF\-PEF (LVEF greater than or equal to 50% within 6m of randomisation)
- •NYHA II\-III
- •Diastolic dysfunction on echo
- •E/A equal to 1, E/E’ equal to or greater than 15, deceleration time less than or equal to 140ms
- •Heart rate over 70/min
- •Stable disease, confirmed by no hospital admissions or HF medication changes within 3m prior to randomisation
- •Informed consent
- •No other causes for exertional dyspnoea
Exclusion Criteria
- •Atrial Fibrillation
- •Contraindications to MRI
- •Significant valvular or coronary disease as primary cause of HF
- •Hypertrophic cardiomyopathy, cardiac amyloidosis, sarcoidosis
- •GFR equal to or greater than 45 ml/min
Outcomes
Primary Outcomes
Not specified
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