Safety and Efficacy of Atiprimod for Patients With Refractory Multiple Myeloma

Phase 1

Completed

• Conditions: Multiple Myeloma

• Registration Number: NCT00086216
• Lead Sponsor: Callisto Pharmaceuticals

Brief Summary

This is a Phase I/IIa clinical trial to identify the maximum tolerated dose of atiprimod and to evaluate the safety of atiprimod in patients with refractory or relapsed multiple myeloma.

Detailed Description

This is a multi-center, open-label, dose escalation study intended to identify the MTD of atiprimod alone and the MTD of atiprimod when given in combination with ursodiol. The atiprimod dose will be escalated in sequential cohorts. Ten dose levels of atiprimod are planned for the atiprimod alone dose escalation: 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 mg/day to be given orally. Six dose levels of atiprimod are planned for the atiprimod in combination with ursodiol dose escalation: 180, 240, 300, 360, 420, and 480 mg/day to be given orally. The dose of ursodiol will remain constant for all cohorts (300 mg ursodiol orally three times a day everyday). Up to 105 patients will participate depending on the level at which toxicity is observed. Patients will be assigned to dose level in the order of study entry.

Study Timeline

• Study Start: 2004-05
• Study First Submitted: 2004-06-28
• Study First Submitted QC: 2004-06-29
• Study First Posted: 2004-06-30
• Study Completion: 2007-11
• Status Verified: 2007-12
• Last Update Submitted: 2007-12-20
• Last Update Posted: 2007-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• documented history of multiple myeloma,
• failed at least two prior regimens for multiple myeloma,
• 18 years of age or older,
• ECOG(Zubrod)PS of 0 to 2,
• screening evaluation for determining eligibility prior to enrollment,
• signed informed consent form,

Exclusion Criteria

• concomitant therapy medications including corticosteroids or other chemotherapy that is or may be active against myeloma ,
• renal insufficiency (serum creatinine levels of > 2mg/dL),
• mucosal bleeding,
• any condition which in the opinion of the Investigator, places the patient at unacceptable risk if he/she were to participate in the study.
• clinically relevant active infection or co-morbid medical conditions.
• prior malignancy(within the last 3 years) except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient is has been disease-free for at least 3 years.
• patients with non-secretory myeloma.
• as atiprimod is a potent inhibitor or CYP2D6, patients taking drugs that are substrates of CYP2D6(e.g. beta blockers, antidepressants and antipsychotics) will be excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
The primary objective of this study is to identify the maximum tolerated dose	1 year

Secondary Outcome Measures

Name	Time	Method
The secondary objective of this study is to measure the pharmacokinetics of	1 year

Trial Locations

Locations (1)

MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States