Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia

Completed

• Conditions: Ventricular Tachycardia
• Interventions: Other: Data Collection Forms

• Registration Number: NCT01695551
• Lead Sponsor: Dhanunjaya Lakkireddy, MD, FACC

Brief Summary

Ventricular tachycardia (VT) is a life-threatening, fast heart rhythm that starts in the lower chambers of the heart (the ventricles). This fast heartbeat is caused by abnormal electrical pathways located in the heart tissue. A standard procedure called a catheter ablation has been used for several years to help correct these abnormal pathways and, in some cases, improve or even eliminate the ventricular tachycardia.

During a VT ablation it is routine to monitor your vital signs (blood pressure, heart rate, and oxygen saturation in your blood). If you choose to participate in this study we will also monitor your cerebral oximetry, the amount of blood flow and oxygen saturation to your brain during the ablation.

By doing this study, we hope to have a better understanding of patients' blood and oxygen flow to their brain during an episode of Ventricular Tachycardia (VT).

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-07-05
• Study First Submitted QC: 2012-09-26
• Study First Posted: 2012-09-28
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-05
• Last Update Posted: 2017-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Able to give informed consent
• Have implantable defibrillator in-situ and are undergoing ablation procedure for ventricular tachycardia

Exclusion Criteria

• Patients who have been hypotensive with systolic blood pressure of < 80mm Hg prior to procedure
• Cerebral event as defined by Cerebrovascular Accident or Transient Ischemia Attack within six months prior to procedure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Ventricular Tachycardia	Data Collection Forms	Participants in cohort will have implantable defibrillators in-situ and are undergoing ablation procedure for ventricular tachycardia.

Primary Outcome Measures

Name	Time	Method
Identify clinical, EKG and EGM characteristics of hemodynamically unstable VT	Change from Baseline to 24-48 hours after surgery	The investigator will be evaluating the relationship of the oxygenation level of the brain during a Ventricular Tachycardia ablation.

Secondary Outcome Measures

Name	Time	Method
MMSE to determine cerebral function before and after VT ablation	24 hours after surgery	The use of the Mini-Mental Status Exam prior to the ablation will serve as a reference point and will be repeated 24 hours post exam.

Trial Locations

Locations (1)

University of Kansas Medical center; 🇺🇸 Kansas City, Kansas, United States