NCT00962949已完成1 期
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Mean Arterial Blood Pressure Change
研究概览
简要总结
The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
- •Age between 18-64 years
- •Male or females are eligible
- •Able and willing to provide informed consent
- •Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study
排除标准
- •Overt cause of postural tachycardia e.g., dehydration
- •Inability to give or withdraw informed consent
- •Pregnancy
- •Hypertension (BP > 140/90)
- •Significant co-morbid condition
- •Other factors which in the investigator's opinion would prevent the subject from completing the protocol
研究组 & 干预措施
Control
Experimental
Healthy controls
干预措施: Angiotensin II (Drug)
Postural Tachycardia Syndrome
Experimental
Patients with Postural Tachycardia Syndrome
干预措施: Angiotensin II (Drug)
结局指标
主要结局
Mean Arterial Blood Pressure Change
时间窗: 1 hour
Change in MAP from baseline to after 1h of infusion.
次要结局
- Plasma Renin Activity(1 hour)
- Aldosterone Level(1 hour)
- Cortisol Level(1 hour)
研究者
Satish R. Raj
Adjunct Assoc Professor
Vanderbilt University Medical Center
研究点 (1)
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