The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
Phase 1
Completed
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS)
- Interventions
- Registration Number
- NCT00962949
- Lead Sponsor
- Vanderbilt University Medical Center
- Brief Summary
The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
- Age between 18-64 years
- Male or females are eligible
- Able and willing to provide informed consent
- Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study
Exclusion Criteria
- Overt cause of postural tachycardia e.g., dehydration
- Inability to give or withdraw informed consent
- Pregnancy
- Hypertension (BP > 140/90)
- Significant co-morbid condition
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Angiotensin II Healthy controls Postural Tachycardia Syndrome Angiotensin II Patients with Postural Tachycardia Syndrome
- Primary Outcome Measures
Name Time Method Mean Arterial Blood Pressure Change 1 hour
- Secondary Outcome Measures
Name Time Method Aldosterone Level 1 hour Plasma Renin Activity 1 hour Cortisol Level 1 hour
Trial Locations
- Locations (1)
Vanderbilt University
🇺🇸Nashville, Tennessee, United States