Genetics of Aortic Stenosis: From Family Forms to the Common Forms

Nantes University Hospital3 sites in 1 country1,987 target enrollmentJanuary 2009

ConditionsAortic Stenosis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Aortic Stenosis
Sponsor: Nantes University Hospital
Enrollment: 1987
Locations: 3
Primary Endpoint: identify the genetic factors involved in the occurrence of aortic stenosis
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The association study will compare the allele frequencies of polymorphisms of a single nucleotide (SNP) in the population of individuals with aortic stenosis compared to a control population.

Patients will be included only if they are suffering from a typical form of tight and surgical tricuspid aortic stenosis. Patients will therefore only included if they are suffering from aortic stenosis, the surface is less than 1 cm² and if histological analysis or failing intraoperative findings of the surgeon showed a tricuspid aortic stenosis.

Registry

clinicaltrials.gov

Start Date

January 2009

End Date

December 2013

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Nantes University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Criteria has reached:
•That patients are operated or not, they can be considered as having a degenerative aortic stenosis, patients will be diagnosed with aortic stenosis (aortic area \<1 cm) without obvious cause found.
•criteria not met
•Strictly normal aortic valve by ultrasound in an over 65-year-old patient.
•All patients do not fit into the above two categories are considered as having an unknown phenotype and will not be used in binding assays. In particular, the presence of an aortic sclerosis or even moderate aortic regurgitation can be considered as potentially incipient form of aortic stenosis, patients with this type of anomaly will not be scanned during family analyzes.