Identification of Prognostic Gene Mutations in Biliary Tract Cancer Using Whole Genome Sequencing
- Conditions
- Biliary Tract Cancer
- Registration Number
- NCT03718897
- Lead Sponsor
- Ji Kon Ryu
- Brief Summary
The purpose of this study is to investigate genetic mutations affecting prognosis using whole genome sequencing in patients with biliary tract cancer.
- Detailed Description
Recently, as genome technology such as next-generation sequencing has progressed, precision medicine using genetic analysis in lung cancer, colorectal cancer, and melanoma has been actively studied. The need for such precision medicine is also increasing in biliary tract cancer patients. Although whole genome sequencing is relatively costly, it is known to provide more accurate information than other methods such as exome analysis and RNA sequencing in identifying promoter mutations, regulatory regions, and structural variants. Pancreatic cancer and melanoma have been studied by whole genome sequencing, but there is no previous study using whole genome sequencing method in biliary tract cancer.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Patients diagnosed with biliary tract cancer via endoscopic retrograde cholangiopancreatogram
- Pregnancy
- Other active tumors within 5 years
- Coagulopathy
- Severe mental illness
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Overall survival rate 48 months Comparisons of overall survival rates between patients with gene mutations and without.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of