Effect of angiotensin II receptor type 1 blocker and branched-chain amino acids on small intestinal pathological lesions in patients with liver cirrhosis

Not Applicable

• Conditions: iver cirrhosis

• Registration Number: JPRN-UMIN000012065
• Lead Sponsor: The third department of internal medicine, Nara Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-10-21
• Study Completion: 2018-09-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patients with malignant tumor 2) Patients with severe heart disease 3) Patients with severe and active infectious disease except viral hepatitis 4) Patients with HIV 5) Patients with severe renal dysfunction 6) Patienst with intracranial tumor 7) Patients with on going refractory hepatic coma 8) Patients with refractory ascites and pleural effusion 9) Patients with crutial digestive bleedings within 4 weeks 10) Ptients with intravascular thrombosis within 6 months except portal thrombosis 11) Patients with the following issues a. Systemic chemotherapy against HCC b. Partial hepatectomy or local treatment against HCC within 4 weeks c. Being treated with anticoagulant drugs d. Being treated with invasive surgical therapy within 4 weeks e. Having been treated with organ transplantation f. Being treated with bone marrow transplantation within 4 weeks 12) Patients with oral intake difficulty 13) Patients with severe digestive diseases 14) Patients taking a tablet which would affect this clinical study 15) Patients without normal absorbing function 16) Patients having been resistered in other clinical study within 4 weeks 17) Pregnant woman, lactating woman, or a woman suspected of pregnancy 18) Patients with severe allergic reaction 19) Patients with drug abuse or psycological disorders 20) Patients taking aliskiren hemifumarate 21) Patients concluded to be inappropriate to participate in this study by their physitians

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periods between the date of primary resistration and the date of newly occurred varices recognition in digestive organs

Secondary Outcome Measures

Name	Time	Method
Periods between the date of primary resistration and the date of varices rupture (or very similar situation to rupture) in digestive organs