High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in PTSD
- Conditions
- PTSD, Post Traumatic Stress Disorder
- Registration Number
- NCT02873299
- Lead Sponsor
- United States Naval Medical Center, San Diego
- Brief Summary
The purpose of this study is to compare two slightly different methods of transcranial magnetic stimulation (TMS) to treat Post Traumatic Stress Disorder (PTSD)
- Detailed Description
This is a randomized single-blind pilot study investigating the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex at either 10 Hz or 20 Hz as compared to a treatment as usual group for the treatment of Post Traumatic Stress Disorder (PTSD) symptoms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
- Willing and able to give informed consent
- Diagnosis of Post-Traumatic Stress Disorder as determined by the SCID
- CAPS score of at least 40
- Males or females between 18-65 years of age
- Willing to give up new psychotherapy or changes in psychiatric medications during the course of the TMS treatment.
- Current primary Axis I disorder including Schizophrenia, Bipolar Disorder type I, Major Depressive Disorder
- Patients with HDRS score ≥ 18
- A metallic implant in cranium (except the mouth)
- Patients with severe or unstable medical conditions, which in the opinion of the investigator would interfere with their progress or safety
- ECT treatment within the last three months
- Patients with a history of epilepsy
- Patients with neurological disorder leading to increased intracranial pressure
- Participation in a new course of psychotherapy during the 24 days of the study
- A new psychiatric medication within 6 weeks of enrolling in the study
- Changes in psychiatric medication within 2 weeks of starting the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Clinician Administered PTSD Scale , CAPS day 10 The CAPS is the gold-standard, semi-structured interview that corresponds to DSM-IV criteria for PTSD.
- Secondary Outcome Measures
Name Time Method Posttraumatic Stress Disorder Checklist, PCL week 24 The PCL consists of 17 items measured on a 5-point Likert scale ranging from "not at all" to "extremely
Trial Locations
- Locations (1)
NMCSD
🇺🇸San Diego, California, United States
NMCSD🇺🇸San Diego, California, United States