Relationship Between "FODMAPs" and "GVHD"

Recruiting

• Conditions: Graft Versus Host Disease

• Registration Number: NCT04660487
• Lead Sponsor: The First Affiliated Hospital of Soochow University

Brief Summary

With the stem cell transplanting increasing, patients which effected with "GVHD" were also increased. To evaluation the relationship between "FODMAPs" and "GVHD", Bone marrow transplant patients were recruited.

Detailed Description

The feces were collected from the patients who had been successfully transplanted after bone marrow transplantation. After 24 hours of culture in the culture medium, the degradation rate of "FODMAPs" was detected, and the relationship between the degradation rate and the occurrence time and degree of "GVHD" was observed

Study Timeline

• Study Start: 2020-12-01
• Study First Submitted: 2020-12-03
• Study First Submitted QC: 2020-12-03
• Study First Posted: 2020-12-09
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-08
• Last Update Posted: 2024-04-10
• Primary Completion: 2026-12-01
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Clinical diagnosis of "AML","ALL","MDS" or "MM" Disease;
2. Must be treated with bone marrow transplantation;
3. The transplanted bone marrow was successfully planted

Exclusion Criteria

1. Gastrointestinal diseases；
2. Age>60; or Age<10；
3. Probiotics or prebiotics were taken before enrollment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurrence of GVHD	90 days	The occurrence time and degree of GVHD

Trial Locations

Locations (1)

中国; 🇨🇳 Suzhou, Jiangsu, China