Effects of Physical Training on Sensitivity Baroreflex Patients Without Chagas' Heart Ventricular Systolic Dysfunction
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Sympathetic nerve activityAutonomic control
研究概览
简要总结
The prevalence of Chagas' disease continues high even in the developed countries. Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.
详细描述
Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chagas' disease patients, diagnosed with at least two positive serological reactions to Chagas' disease,
- •Ejection fraction ≥55%
排除标准
- •Participation in a regular exercise program in the last 3 months preceding the survey
- •Use of oral anticoagulant
- •Use of a pacemaker or implantable cardioverter
- •Hemodynamic instability
- •Myocardial revascularization infarction or unstable angina in the last 3 months of the start of the protocol
- •Diabetes mellitus
- •Hypertension
- •Pulmonary Disease
- •Valvular lesions
- •Atrial Fibrillation
- •Angina of effort
研究组 & 干预措施
Sedentary Group
The patients will not do exercise training
Trained Group
The patients will do exercise training for sixteen weeks.
干预措施: Exercise (Other)
结局指标
主要结局
Sympathetic nerve activityAutonomic control
时间窗: 4 months
Exercise training will improve baroreflex sensitivity and reduce sympathetic nerve activity.
次要结局
- Skeletal muscle strength(4 months)
- Peak oxygen consumption(4 months)