Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
- Conditions
- Intractable Epilepsy
- Interventions
- Procedure: Observation
- Registration Number
- NCT02846272
- Brief Summary
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.
- Detailed Description
To determine if diffusion tensor and functional connectivity magnetic resonance imaging helpful to better understand and diagnose intractable epilepsy in children. All enrolled children will undergo standard preoperative and postoperative MRI imaging, plus a 15 minute set of functional connectivity and diffusion tensor sequence with no additional sedation. This imaging data will be stripped of identifiers and be processed to provide both quantitative analysis, resting state functional connectivity changes and three dimensional modeling of white matter tracts adjacent to epileptogenic foci. This study is being done to determine if diffusion tensor and functional connectivity magnetic resonance imaging are helpful to better understand and diagnose intractable epilepsy in children.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Children diagnosis with Intractable Epilepsy
- No Intractable Epilepsy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Observational cohort Observation Observing MRI changes in subjects.
- Primary Outcome Measures
Name Time Method Number of participants with seizure outcome as determined by Engel 5 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UTHealth & Children's Memorial Hermann Hospital
🇺🇸Houston, Texas, United States