Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intractable Epilepsy
- Sponsor
- The University of Texas Health Science Center, Houston
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Number of participants with seizure outcome as determined by Engel
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.
Detailed Description
To determine if diffusion tensor and functional connectivity magnetic resonance imaging helpful to better understand and diagnose intractable epilepsy in children. All enrolled children will undergo standard preoperative and postoperative MRI imaging, plus a 15 minute set of functional connectivity and diffusion tensor sequence with no additional sedation. This imaging data will be stripped of identifiers and be processed to provide both quantitative analysis, resting state functional connectivity changes and three dimensional modeling of white matter tracts adjacent to epileptogenic foci. This study is being done to determine if diffusion tensor and functional connectivity magnetic resonance imaging are helpful to better understand and diagnose intractable epilepsy in children.
Investigators
Manish Narendra Shah
M.D. , Assistant Professor
The University of Texas Health Science Center, Houston
Eligibility Criteria
Inclusion Criteria
- •Children diagnosis with Intractable Epilepsy
Exclusion Criteria
- •No Intractable Epilepsy
Outcomes
Primary Outcomes
Number of participants with seizure outcome as determined by Engel
Time Frame: 5 years