Endophenotype Characterization of a Family Psychiatric Disorder

Not Applicable

• Conditions: Healthy Volunteer
• Interventions: Genetic: Endophenotype and sequencing

• Registration Number: NCT02843997
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.

The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.

Detailed Description

Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.

The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.

Study Timeline

• Study Start: 2015-02
• Status Verified: 2016-07
• Study First Submitted: 2016-07-11
• Study First Submitted QC: 2016-07-22
• Last Update Submitted: 2016-07-22
• Study First Posted: 2016-07-26
• Last Update Posted: 2016-07-26
• Primary Completion: 2018-02
• Study Completion: 2018-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Members of a family adult (more than 18 years)
• Signed informed consents
• Registered to a French social security or possesor of the European Health Insurance Card

Exclusion Criteria

Clinical part :

• Refusal to sign the participation study consent.
• Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.

Genetic part :

• Refusal to sign the genetic sample consent.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy volunteers	Endophenotype and sequencing	Members of a family

Primary Outcome Measures

Name	Time	Method
Neuropsychological evaluations tests	One day	Neuropsychological evaluations (about one hour) : TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests.
Eye tracking.	One hour	The volunteer will follow an instruction according to the color seen on a screen.; This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken.; Mistakes will be count.
Blood sampling	3 minutes	Genetic sample for extraction of DNA.

Trial Locations

Locations (1)

UniversityHospitalGrenoble; 🇫🇷 La Tronche, France