ACTRN12615001240538已完成未知
Comparative effects of intraduodenal (ID) vs. intraileal (II) glucose on incretin hormone secretion, incretin effect, and glycaemic excursions in healthy subjects and patients with type 2 diabetes.
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Type 2 diabetic subjects
- •*Managed by diet alone (i.e. no oral hypoglycaemic drugs or insulin)
- •*Body mass index (BMI) 20 - 35 kg/m2
- •*Age 18 - 75 years
- •*Males and post-menopausal females (to control for the effect of the menstrual cycle on gut hormone secretion)
- •*Glycated haemoglobin (HbA1c) greater than or equal to 6.0% and less than or equal to 7.9%
- •*Haemoglobin above the lower limit of the normal range (i.e. >135g/L for men and 115g/L for women), and ferritin above the lower limit of normal (i.e. >10mcg/L)
- •Healthy subjects
- •*Male and postmenopausal females aged 18 – 75 years
- •*Body mass index (BMI) 20 - 35 kg/m2
- •*Age- and BMI-matched to the diabetic subjects
排除标准
- •*Use of any medication that may influence BP, gastrointestinal motor function, body weight or appetite (e.g. antihypertensive drugs, domperidone and cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St. John's Wort etc.)
- •*Evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
- •*History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
- •*Other significant illness, including epilepsy, cardiovascular or respiratory disease
- •*Impaired renal or liver function (as assessed by calculated creatinine clearance < 90 mL/min or abnormal liver function tests (> 2 times upper limit of normal range))
- •*Donation of blood within the previous 3 months
- •*Participation in any other research studies within the previous 3 months
- •*Females who are pre-menopausal
- •*Inability to give informed consent
- •*Vegetarians
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