ACTRN12615001240538
Completed
未知
Comparative effects of intraduodenal (ID) vs. intraileal (II) glucose on incretin hormone secretion, incretin effect, and glycaemic excursions in healthy subjects and patients with type 2 diabetes.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Glucose metabolism
- Sponsor
- Royal Adelaide Hospital
- Enrollment
- 32
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type 2 diabetic subjects
- •\*Managed by diet alone (i.e. no oral hypoglycaemic drugs or insulin)
- •\*Body mass index (BMI) 20 \- 35 kg/m2
- •\*Age 18 \- 75 years
- •\*Males and post\-menopausal females (to control for the effect of the menstrual cycle on gut hormone secretion)
- •\*Glycated haemoglobin (HbA1c) greater than or equal to 6\.0% and less than or equal to 7\.9%
- •\*Haemoglobin above the lower limit of the normal range (i.e. \>135g/L for men and 115g/L for women), and ferritin above the lower limit of normal (i.e. \>10mcg/L)
- •Healthy subjects
- •\*Male and postmenopausal females aged 18 – 75 years
- •\*Body mass index (BMI) 20 \- 35 kg/m2
Exclusion Criteria
- •\*Use of any medication that may influence BP, gastrointestinal motor function, body weight or appetite (e.g. antihypertensive drugs, domperidone and cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St. John's Wort etc.)
- •\*Evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
- •\*History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
- •\*Other significant illness, including epilepsy, cardiovascular or respiratory disease
- •\*Impaired renal or liver function (as assessed by calculated creatinine clearance \< 90 mL/min or abnormal liver function tests (\> 2 times upper limit of normal range))
- •\*Donation of blood within the previous 3 months
- •\*Participation in any other research studies within the previous 3 months
- •\*Females who are pre\-menopausal
- •\*Inability to give informed consent
- •\*Vegetarians
Outcomes
Primary Outcomes
Not specified
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