Radiotherapy in globlastoma (brain tumor) patients
Phase 1
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2019/05/019146
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Biopsy Proven case of GBM
Age >= 18 years, < 70 years
Karnofsky Performance Status >= 60
Adequate bone marrow reserve
Exclusion Criteria
Age < 18 years
H/o prior malignancy
Unwilling for written informed consent and follow-up
Major medical illness or psychiatric impairment that will prevent completion of the protocol
or would interfere with follow-up
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To evaluate the feasibility of radiotherapy dose escalation based on 68Ga-Pentixafor-PET/CT scan in Globlastoma patients <br/ ><br>2.To see the impact of dose escalation on response rate and survival <br/ ><br>Timepoint: One year from the date of last patient enrollment <br/ ><br>
- Secondary Outcome Measures
Name Time Method To see the incidence of radio-necrosis <br/ ><br>To assess the quality of life <br/ ><br>To assess neuro-cognitive dysfunction <br/ ><br>Timepoint: After completion of treatment every three monthly evaluation to assess radio-necrosis status and quality of life up to one year