Evaluation of serum markers to differentiate high blood pressure of pregnancy from kidney disease of lupus
Not Applicable
Recruiting
- Conditions
- systemic lupus erythematosus, preeclampsia
- Registration Number
- RBR-3fwgnj
- Lead Sponsor
- niversidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Pregnant patients diagnosed with systemic lupus erythematosus between will be sequentially enrolled upon prenatal admission.
Exclusion Criteria
Patients who do not wish to participate in the study; multiple pregnancies; pregnancies that are interrupted before 20 weeks.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected primary outcome 1: Diagnose patients with preeclampsia by measuring blood pressure (BP> or = 140 x 90 mmHg) and 24-hour proteinuria> or = 300 mg / 24 hours.<br>;Expected primary outcome 2: Diagnose patients with active lupus using the SLEPDAI index. Will be considered active lupus when SLEPDAI is greater than or equal to 4
- Secondary Outcome Measures
Name Time Method Expected secondary outcome 1: Diagnose intrauterine growth restriction, based on estimated fetal weight on ultrasound lower than percetile 10 for gestational age.<br>;Expected secondary outcome 2: Diagnose lupus renal activity, using the SLEPDAI index with at least one positive renal parameter.<br>;Expected secondary outcome 3: Diagnose fetal death, defined by the absence of fetal heartbeat after 10 weeks, confirmed by ultrasound.