Comparing the Effects of Multicomponent Exercise on Cardiovascular Health and Lipid Profiles in Premenopausal and Postmenopausal Women

Not Applicable

Completed

• Conditions: Menopause; Cardiovascular

• Registration Number: NCT06802484
• Lead Sponsor: University of Évora

Brief Summary

Background: The present study aimed to examine the effects of a 26-week multicomponent exercise program on lipid and lipoprotein profiles, blood pressure, and anthropometric parameters in healthy but sedentary premenopausal and postmenopausal women aged 40-60.

Method: The program, comprising resistance, balance, flexibility, and aerobic exercises, aimed to identify group-specific responses and establish the program's efficacy in mitigating cardiovascular risks. Seventy-five women were recruited, and 38 completed the intervention. Participants were categorized into premenopausal (n=18), postmenopausal (n=10), and control groups (n=10). Key measures included total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, systolic and diastolic blood pressure, and anthropometric variables. Statistical analyses employed the Shapiro-Wilk test, paired t-tests, Wilcoxon tests, and Kruskal-Wallis tests, with α=0.05.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-01
• Primary Completion: 2024-08-01
• Study Completion: 2024-12-31
• Status Verified: 2025-01
• Study First Submitted: 2025-01-16
• Study First Submitted QC: 2025-01-24
• Last Update Submitted: 2025-01-24
• Study First Posted: 2025-01-31
• Last Update Posted: 2025-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 75

Inclusion Criteria

• women aged between 40 and 60 years old;
• healthy, asymptomatic, and non-smoking;
• medical diagnosis favouring the engagement in physical-sporting activities;
• absence of clinical history related to alcoholism or uncontrolled metabolic disease;
• no clinical prescription for hypotensive pharmacological intake, cholesterol reduction, hormonal replacement therapy, or any other intervention capable of inducing alterations in lipid and lipoprotein metabolism; or
• abnormal blood sample results.

Exclusion Criteria

• non-fulfilment of inclusion criteria;
• clinical history characterized by symptoms related to cardiovascular disease (CVD), including stroke (CVA) and coronary vascular disease (CVD), renal or hepatic disease, musculoskeletal disorders, or rheumatoid conditions that may impede full participation in the exercise program.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Systolic Blood Pressure	26-week
Diastolic Blood Pressure	26-week
Heart Rate	26-week
Body Mass Index	26-week
Waist Circumference	26-week
Hip Circumference	26-week
Total Cholesterol	26-week
Low-density lipoprotein Cholesterol	26-week
High-density lipoprotein Cholesterol	26-week
Triglycerides	26-week
Castelli Risk Index I	26-week
Castelli Risk Index II	26-week
Very Low-Density Lipoprotein Cholesterol	26-week
Glucose	26-week
Waist Circumference/ Hip Circumference	26-week

Trial Locations

Locations (1)

Bruno Figueira; 🇵🇹 Évora, Portugal