A Retrospective Study of the Efficacy of Compound Lactobacillus Acidophilus Combined With Bismuth Quadruple Rescue Therapy on Patients With H Pylori Eradication Failures
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- urea breath test
研究概览
简要总结
Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme.
详细描述
H pylori infection rate has been up to half of the world population. H pylori infection is associated with various diseases, especially gastric cancer.
With the increasingly resistant to antibiotics,the eradication rate has decreased a lot with traditional triple therapy. Exploring a valid scheem for patients who have failed multiple times is important.
Probiotics can improve gastrointestinal microenvironment, then release the adverse effects during the eradication process.Additionally,there is also a lot evidence that probiotics can inhibit H plori，but still controversially.
There is a low resistant rate about furazolidone and tetracycline. In this study investigators observe the efficacy of the therapy 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme on patients who have failed more than 2 times. 4 to 6 weeks after the therapy, if Urea Breath Test (UBT) is nedative which means eradicating H plori successfully.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •H pylori eradication had failed more than 2 times
- •Patients had never used furazolone and tetracycline
- •The age varied from 18 to 80 years old
排除标准
- •H pylori initial eradication or had failed only 1 time
- •The age was lower than 18,or higher than 80 years old
- •Patients who had serious heart pulmonary disease ,live renal disease, or any cancers
- •Pregnant women
结局指标
主要结局
urea breath test
时间窗: 4-6 weeks after the quadruple therapy
if urea breath test is negative,it means H pylori eradicated successfully
次要结局
- adverse effects(1month)
研究者
Zhaoshen Li
director of the Digestive Department
Changhai Hospital