Daily Physical Activity After Meals -Long Term Effects on Blood Glucose
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in Physical fitness measured as oxygen consumption during an exercise test
研究概览
简要总结
The postprandial blood glucose concentration is an important risk factor for development of cardiovascular diseases and diabetes. Previous studies have shown that one bout of moderate or light post-meal physical activity effectively blunts the postprandial increase in blood glucose after carbohydrate intake. Pre-meal exercise does not generate such effect. Thus, the effect of exercise on postprandial glycemia depend on the timing of exercise. Even very light physical activity decreases postprandial glycemia when performed in the postprandial period. The purpose of this study was to investigate whether such activity performed each day for 12 weeks would influence blood variables related to glycemic control.
METHODS 40 subjects being ethnic Norwegians or of South Asian origin were randomized into an intervention or a control group. They were previously diagnosed as hyperglycemic, or with high risk of type 2 diabetes according to Ramachandran's risc score.
Control subjects were told to maintain their usual physical activity patterns during the study period, while the intervention subjects were instructed to undertake a minimum of 30 minutes of daily post-meal physical activity in addition to their usual activity patterns.
Venous blood samples were taken before and after the 12 week intervention period. Plasma was analyzed for HbA1c and for fasting and 2hour (OGTT) values of glucose, insulin and c-peptide. The subjects kept a physical activity diary, answered questionnaires and used accelerometers to determine the level of physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hyperglycemia or high risk of type 2 diabetes due to Ramachandrans risk score
排除标准
- •Use of hypoglycemic agents and conditions directly affecting blood glucose other than hyperglycemia per s.e. / diabetes type 2
结局指标
主要结局
Change in Physical fitness measured as oxygen consumption during an exercise test
时间窗: Measured pre and post intervention which lasts an average of 12 weeks
measured at the end of 10 minutes ergometer cycle test an given intensity (low) by indirect calorimetry
Change in Fasted glucose
时间窗: Pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as lactic acid during an exercise test
时间窗: Measured pre and post intervention which lasts an average of 12 weeks
measured at the end of 10 minutes ergometer cycle test an given intensity (low) from capillary blod from a finger stick
Change in Hba1c
时间窗: Pre and post intervention which lasts an average of 12 weeks
Change in 2hour glucose
时间窗: Pre and post intervention which lasts an average of 12 weeks
Oral glucose tolerance test (OGTT)
Change in Physical fitness measured as heart rate during an exercise test
时间窗: Measured pre and post intervention which lasts an average of 12 weeks
Heart rate measured at the end of 10 minutes ergometer cycle test an given intensity (low) to moderate intensity)
Change in Physical fitness measured as perceived exertion during an exercise test
时间窗: Measured pre and post intervention which lasts an average of 12 weeks
Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low)
Change in glucose during OGTT
时间窗: Pre and post intervention which lasts an average of 12 weeks
glucose measured by finger sticks every 15. minute during the 2hour oral glucose tolerance test
Change in Physical fitness measured as respiratory exchange rate during an exercise test
时间窗: Measured pre and post intervention which lasts an average of 12 weeks
Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry
次要结局
- Change in LDL cholesterol(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in triglycerides(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in Blood pressure(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in Quality of life(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in Total cholesterol(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in body weight(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in HDL cholesterol(Measured Pre and post intervention which lasts an average of 12 weeks)
- Change in waist circumference(Measured Pre and post intervention which lasts an average of 12 weeks)