Comparison the Value of Several Biomarkers of Sepsis

Completed

• Conditions: Systemic Inflammatory Response Syndrome; Sepsis

• Registration Number: NCT01388725
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

The purpose of this study is to describe the value of serum sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score during sepsis and their clinical informative value in predicting outcome.

Detailed Description

The investigators enrolled 130 subjects admitted to an ICU: 30 cases with systemic inflammatory response syndrome (SIRS), 36 cases with sepsis, 35 cases with and 29 with septic shock. Results for sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score were recorded on days 1, 3, 5, 7, 10, and 14.

Study Timeline

• Study Start: 2009-09
• Status Verified: 2010-07
• Primary Completion: 2011-07
• Study Completion: 2011-07
• Study First Submitted: 2011-07-05
• Study First Submitted QC: 2011-07-06
• Last Update Submitted: 2011-07-06
• Study First Posted: 2011-07-07
• Last Update Posted: 2011-07-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• Male and female aged 18 years old and over;
• Clinically suspected infection;
• Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than < 4,000/μl or less than 10% of bands.

Exclusion Criteria

• Those who fulfilled one below:
• neutropenia (≤ 500 neutrophils/mm3)
• HIV infection, and
• patients or their relatives refused

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patients Outcome	28 days	The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China