The Effect of Mannitol on the Serum Potassium During Craniotomy
Completed
- Conditions
- HyperkalemiaMannitol Adverse Reaction
- Interventions
- Other: Mannitol
- Registration Number
- NCT03161977
- Brief Summary
This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.
- Detailed Description
Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- age 18 to 70
- American Society of Anesthesiologists physical status I to II
- liver and kidney function is normal
- preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L
Exclusion Criteria
- history or presence of congestive heart failure (New York Heart Association class III to IV)
- history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion)
- intraoperative blood transfusion
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Mannitol Mannitol Mannitol was intravenous infused within 15-20 mins when drilling skull
- Primary Outcome Measures
Name Time Method the concentration of serum potassium two hours within infusioning mannitol measured by arterial blood gas analysis
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, Jiangsu, China