Potential Beneficial Effects of Resveratrol
- Conditions
- Metabolic SyndromeObesity
- Interventions
- Dietary Supplement: ResveratrolOther: Placebo
- Registration Number
- NCT01150955
- Lead Sponsor
- University of Aarhus
- Brief Summary
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
- Detailed Description
The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 24
- BMI > 30 kg/m2
- Otherwise healthy
- Written informed consent
- Any disease
- Alcohol dependency
- Allergy to trial medication
- Present or previous malignancy
- Participation in other clinical trials within three months before randomization
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Resveratrol Resveratrol Dietary supplement of resveratrol 500 mg three times a day over five weeks. Placebo Placebo -
- Primary Outcome Measures
Name Time Method Metabolic parameters Five weeks Regarding glucose, protein and fat metabolism.
- Secondary Outcome Measures
Name Time Method Pathways of substrate metabolism. Five weeks Description of the biochemical pathways underpinning the interplay between calorie restriction, SIRT1, STAT5 and the GH/IGF-I axis.
Trial Locations
- Locations (1)
Aarhus University Hospital, Department of Endocrinology, MEA
🇩🇰Aarhus, Denmark