A feasibility and safety study of bronchoscopic intrabullous autologous blood instillation for the treatment of severe bullous emphysema. - BIABI study

niversitair Medisch Centrum Groningen0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Age > 35 years
•- Large bulla on CT scan were bullectomy is contraindicated or is actively avoided
•- Hyperinflation --> TLC * 100%predcited and RV * 150% predicted
•- Exertional breathlessness (mMRC >0)
•- Optimum COPD treatment for at least 6 weeks
•- No COPD exacerbation for at least 6 weeks
•- Fewer than 3 admissions for infective exacerbations in the preceding 12 months
•- Written informed consent
•- Patients has stopped smoking for a minimum of 6 months prior to entering the study

•- Inability to obtain informed consent
•- Co-morbidities that would render bronchoscopy or sedation unsafe
•- Anaemia or other reasons precluding venesection
•- Clinically significant bronchiectasis
•- Arrhythmia or cardiovascular disease that poses a risk during procedure
•- Lung nodule requiring further investigation or treatment
•- Subject taking clopidogrel, warfarin, or other anticoagulants and unable to abstain for 5 days pre-procedure

发起方