Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery

Not Applicable

Completed

• Conditions: Platelet-rich Fibrin
• Interventions: Other: standard third molar surgical removal; Other: PRF

• Registration Number: NCT05866965
• Lead Sponsor: Lam Cu Phong

Brief Summary

A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to second molar of the study and control groups after third molar surgical removal.

Sample include of participants who had indication of impacted lower third molars extraction on both sides with symmetrically orientation and same difficult index. All participants had same extraction protocol on both side at Department of Oral surgery, Faculty of Odonto-stomatology, University of Medicine and Pharmacy, Ho Chi Minh City.

Soft tissue healing, periodontal pocket depth and distal bone height were evaluation by an independent investigator.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-01
• Primary Completion: 2021-06-01
• Study Completion: 2021-12-01
• Study First Submitted: 2023-04-27
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-10
• Last Update Submitted: 2023-05-10
• Study First Posted: 2023-05-19
• Last Update Posted: 2023-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Patient over 18 years old.
• Good general health.
• Bilateral lower third molars equivalent in inclination and Pell and Gregory's impaction classification (classification II, III and B, C). The assessment of equivalence between two mandibular third molars was determined on the panoramic radiograph.
• The difference of third molar inclination on both sides not greater than 15 degrees.
• The patient consented to participate in the study after hearing clearly the explanation of purposes and requirements of the study.

Exclusion Criteria

• Patients with any systemic disease contraindicated for surgery.
• Presence of acute inflammation or infection at third molar areas.
• Patients refused to participate in the study, did not comply with treatment or did not come to the follow-up examination as required.
• The difference in surgical time between the two groups was more than 10 minutes.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
control	standard third molar surgical removal	standard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy
PRF	PRF	PRF was applied in third molar socket after removal following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy

Primary Outcome Measures

Name	Time	Method
distal bone resorption	6th postoperative month	resorption of alveolar bone height distal to second molar
periodontal pocket depth	6rst postoperative month	periodontal pocket depth at distal buccal and distal lingual side of second molar

Secondary Outcome Measures

Name	Time	Method
soft tissue healing index	7th postoperative day	soft tissue healing around third molar socket

Trial Locations

Locations (1)

University of Medicine and Pharmacy; 🇻🇳 Ho Chi Minh City, Vietnam