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Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery

Not Applicable
Completed
Conditions
Platelet-rich Fibrin
Interventions
Other: standard third molar surgical removal
Other: PRF
Registration Number
NCT05866965
Lead Sponsor
Lam Cu Phong
Brief Summary

A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to second molar of the study and control groups after third molar surgical removal.

Sample include of participants who had indication of impacted lower third molars extraction on both sides with symmetrically orientation and same difficult index. All participants had same extraction protocol on both side at Department of Oral surgery, Faculty of Odonto-stomatology, University of Medicine and Pharmacy, Ho Chi Minh City.

Soft tissue healing, periodontal pocket depth and distal bone height were evaluation by an independent investigator.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
26
Inclusion Criteria
  • Patient over 18 years old.
  • Good general health.
  • Bilateral lower third molars equivalent in inclination and Pell and Gregory's impaction classification (classification II, III and B, C). The assessment of equivalence between two mandibular third molars was determined on the panoramic radiograph.
  • The difference of third molar inclination on both sides not greater than 15 degrees.
  • The patient consented to participate in the study after hearing clearly the explanation of purposes and requirements of the study.
Exclusion Criteria
  • Patients with any systemic disease contraindicated for surgery.
  • Presence of acute inflammation or infection at third molar areas.
  • Patients refused to participate in the study, did not comply with treatment or did not come to the follow-up examination as required.
  • The difference in surgical time between the two groups was more than 10 minutes.

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
controlstandard third molar surgical removalstandard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy
PRFPRFPRF was applied in third molar socket after removal following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy
Primary Outcome Measures
NameTimeMethod
distal bone resorption6th postoperative month

resorption of alveolar bone height distal to second molar

periodontal pocket depth6rst postoperative month

periodontal pocket depth at distal buccal and distal lingual side of second molar

Secondary Outcome Measures
NameTimeMethod
soft tissue healing index7th postoperative day

soft tissue healing around third molar socket

Trial Locations

Locations (1)

University of Medicine and Pharmacy

🇻🇳

Ho Chi Minh City, Vietnam

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