Comparison of Spinal and General Anesthesia on Systemic Inflammatory Response in Patients Undergoing Percutaneous Nephrolithotomy: Evaluation of SII, SIRI, AISI, NLR, and RDW
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 3
- 主要终点
- Perioperative change in systemic inflammatory indices (SII, SIRI, AISI, NLR, RDW)
研究概览
简要总结
This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) physical status class I-III
- •Patients aged 18 years and older
排除标准
- •American Society of Anesthesiologists (ASA) physical status class IV or V
- •Patients younger than 18 years
- •Active infection or diagnosis of sepsis
- •Malignancy
- •Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- •Use of immunosuppressive therapy
- •Pregnancy
研究组 & 干预措施
Spinal Anesthesia Group
Patients undergoing percutaneous nephrolithotomy under spinal anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.
General Anesthesia Group
Patients undergoing percutaneous nephrolithotomy under general anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.
结局指标
主要结局
Perioperative change in systemic inflammatory indices (SII, SIRI, AISI, NLR, RDW)
时间窗: From preoperative period (within 6 hours before surgery) to postoperative period (6-24 hours after surgery)
Changes in Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW) will be evaluated using routine complete blood count parameters obtained preoperatively and postoperatively.
次要结局
未报告次要终点
研究者
Sevim Şenol Karataş
Specialist in Anesthesiology and Reanimation
Elazıg Fethi Sekin Sehir Hastanesi