Microvascular dysfunction in patients with valvular heart disease
Not Applicable
- Conditions
- Valvular heart disease
- Registration Number
- JPRN-UMIN000022401
- Lead Sponsor
- Chiba University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
Significant stenosis in the left anterior descending artery (LAD), prior myocardial infarction in the LAD territory, acute decompensated heart failure, acute coronary syndrome, pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluating the differences in the index of microcirculatory resistance (IMR) between patients with valvular heart disease (VHD group) and those without valvular heart disease (Non-VHD group)
- Secondary Outcome Measures
Name Time Method Evaluating the differences in coronary flow reserve (CFR) and fractional flow reserve (FFR) between VHD group and Non-VHD group Comparing the number of abnormal IMR and abnormal CFR between VHD group and Non-VHD group Evaluating the relationship between IMR, CFR and FFR and the findings on cardiac catheterization and echocardiography Evaluating the relationship between IMR, CFR and FFR and clinical events Comparison of coronary physiological measurements (IMR, CFR and FFR) between groups divided according to ejection fractions or types of valvular heart disease (i.e. aortic stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) Evaluating the relationship between RHI and coronary physiological measurements (IMR, CFR and FFR) in the VHD group and non-VHD group.