Long-term Safety and Efficacy Study of Lebrikizumab (LY3650150) in Participants With Moderate-to-Severe Atopic Dermatitis (ADjoin)
- Registration Number
- NCT04392154
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
This is designed to assess the long-term safety and efficacy of lebrikizumab for moderate-to-severe atopic dermatitis. It will last up to 33 months.
- Detailed Description
Participants who have completed participation in a Dermira- or Lilly-sponsored lebrikizumab study (parent study), DRM06-AD04, DRM06-AD05, DRM06-AD06, DRM06-AD17 or DRM06- AD18, will be offered the opportunity to enroll in this study. Participants may either be blinded or not blinded, depending on their parent study assignment.
This study will also be open to an additional approximately 100 participants in the United States (addendum) who have not completed participation in a Dermira- or Lilly-sponsored lebrikizumab study. Treatment will not be blinded.
This study will also include an Addendum to extend the study treatment period by an additional 32 weeks and to add a treatment arm testing dosing every 8 weeks. This Addendum will apply to existing study participants in selected countries. Treatment will not be blinded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1153
Participants must meet all the following criteria to be eligible for this study addendum:
- Male or female adults and adolescents (≥12 to <18 years of age and weighing ≥40 kilogram (kg).
- Chronic AD (according to American Academy of Dermatology Consensus Criteria) that has been present for ≥1 year before screening.
- Eczema Area and Severity Index (EASI) score ≥16 at baseline.
- Investigator Global Assessment (IGA) score ≥3 (scale of 0 to 4) at baseline.
- ≥10% body surface area (BSA) of AD involvement at baseline.
- History of inadequate response to treatment with topical medications; or determination that topical treatments are otherwise medically inadvisable.
Open-Label Addendum
Participants meeting any of the criteria below will be excluded from this study addendum:
-
Have received a dose of lebrikizumab in any prior lebrikizumab clinical study.
-
History of anaphylaxis
-
Treatment with topical prescription moisturizers, corticosteroids, calcineurin inhibitors, or phosphodiesterase-4 inhibitors such as crisaborole within 1 week prior to baseline.
-
Treatment with any of the following agents within 4 weeks prior to the baseline.
- Immunosuppressive/immunomodulating drugs (e.g., systemic corticosteroids, cyclosporine, mycophenolate-mofetil, Interferon gamma (IFN-γ), Janus kinase inhibitors, azathioprine, methotrexate, etc.)
- Phototherapy and photochemotherapy (PUVA) for AD.
-
Treatment with the following prior to baseline:
- Immunosuppressive/immunomodulating drugs (e.g., systemic corticosteroids, cyclosporine, mycophenolate-mofetil, IFN-γ, Janus kinase inhibitors, azathioprine, methotrexate, etc.)
- Phototherapy and photochemotherapy (PUVA) for AD.
-
Treatment with the following prior to baseline:
- An investigational drug within 8 weeks or within 5 half-lives (if known), whichever is longer.
- B Cell-depleting biologics, including rituximab, within 6 months.
- Other Biologics within 5 half-lives (if known) or 8 weeks, whichever is longer.
-
Regular use (more than 2 uses per week) of a tanning booth/parlor within 4 weeks of baseline.
-
Treatment with a live (attenuated) vaccine within 12 weeks of the baseline or planned during the study.
-
Uncontrolled chronic disease that might require multiple intermittent uses of oral corticosteroids, e.g., co-morbid severe uncontrolled asthma, (as defined by the investigator).
-
Pregnant or breastfeeding women, or women planning to become pregnant or breastfeed during the study.
-
Evidence of active acute or chronic hepatitis
-
History of human immunodeficiency virus (HIV) infection or positive HIV serology at screening.
-
History of malignancy, including mycosis fungoides, within 5 years before screening, except completely treated in situ carcinoma of the cervix, completely treated and resolved non-metastatic squamous or basal cell carcinoma of the skin with no evidence of recurrence in the past 12 weeks.
Open-Label Extension Addendum Inclusion Criteria:
Have completed Week 100 of Study KGAA and have not yet completed the safety follow-up visit for the main study.
Open-Label Extension Addendum Exclusion Criteria:
Have initiated treatment with a medication prohibited by Study KGAA before addendum baseline. This includes use of biologics for AD (for example, dupilumab and tralokinumab) during the safety follow-up period of Study KGAA.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Lebrikizumab Q2W (Blinded) from Parent Study Lebrikizumab Participants assigned to lebrikizumab Q2W arm will receive investigational product Q2W by SC injection. Some participants will receive loading doses. Lebrikizumab Q2W (Open-Label Addendum) Lebrikizumab Participants enrolling in Open-Label Addendum will receive lebrikizumab Q2W by SC injection after loading doses. Lebrikizumab Q8W (Open-Label Extension Addendum) Lebrikizumab Participants enrolling in Open-Label extension addendum will receive lebrikizumab Q8W by SC injection. Lebrikizumab Q4W (Open-Label Extension Addendum) Lebrikizumab Participants enrolling in Open-Label extension addendum will receive lebrikizumab Q4W by SC injection. Lebrikizumab Q2W (Open-Label) from Parent Study Lebrikizumab Participants assigned to lebrikizumab Q2W (once every 2 weeks) arm will receive investigational product Q2W by subcutaneous (SC) injection. Lebrikizumab Q2W (Open-Label Extension Addendum) Lebrikizumab Participants enrolling in Open-Label extension addendum will receive lebrikizumab Q2W by SC injection. Lebrikizumab Q4W Lebrikizumab Participants assigned to lebrikizumab Q4W (once every 4 weeks) arm will receive investigational product Q4W by SC injection. Intervention assigned: Lebrikizumab balanced with Placebo to maintain the blind between treatment arms.
- Primary Outcome Measures
Name Time Method Percentage of Participants Discontinued from Study Treatment due to Adverse Events through the Last Treatment Visit Baseline to Week 100
- Secondary Outcome Measures
Name Time Method Percentage of Participants with a Response of Investigator Global Assessment (IGA) Score 0 or 1 Baseline to Week 100 Percentage of Participants Achieving Response of Eczema Area and Severity Index-75 (EASI-75) from Baseline of Parent Study Baseline to Week 100
Trial Locations
- Locations (313)
University of Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Modern Research Associates
🇺🇸Dallas, Texas, United States
Paddington Testing Company Inc
🇺🇸Philadelphia, Pennsylvania, United States
AvantDerm
🇨🇦Toronto, Ontario, Canada
California Allergy and Asthma Medical Group + Research Center
🇺🇸Los Angeles, California, United States
Keck School of Medicine University of Southern California
🇺🇸Los Angeles, California, United States
Dermatology Research Associates
🇺🇸Los Angeles, California, United States
LA Universal Research Center, INC
🇺🇸Los Angeles, California, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
University Hospitals Case Medical Center
🇺🇸Cleveland, Ohio, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Dermatology Associates of Seattle
🇺🇸Seattle, Washington, United States
Vitae Research Center, LLC
🇺🇸Miami, Florida, United States
Acevedo Clinical Research Associates
🇺🇸Miami, Florida, United States
International Dermatology Research, Inc.
🇺🇸Miami, Florida, United States
Community Research Foundation Inc
🇺🇸Miami, Florida, United States
Sanchez Clinical Research Inc
🇺🇸Miami, Florida, United States
Miami Dermatology and Laser Research
🇺🇸Miami, Florida, United States
Well Pharma Medical Research Corp.
🇺🇸Miami, Florida, United States
Florida Research Center, Inc
🇺🇸Miami, Florida, United States
Dawes Fretzin Clinical Research Group, LLC
🇺🇸Indianapolis, Indiana, United States
Encore Imaging & Medical Research
🇺🇸Houston, Texas, United States
University Clinical Trials
🇺🇸San Diego, California, United States
University of California, San Diego/Rady Children's Hospital, San Diego - Pediatric & Adolescent Dermatology
🇺🇸San Diego, California, United States
JDR Dermatology Research
🇺🇸Las Vegas, Nevada, United States
Synergy Dermatology
🇺🇸San Francisco, California, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
Unity Clinical Research
🇺🇸Oklahoma City, Oklahoma, United States
Clinical Research Center of Alabama- Birmingham
🇺🇸Birmingham, Alabama, United States
Oregon Dermatology and Research Center
🇺🇸Portland, Oregon, United States
Oregon Medical Research Center
🇺🇸Portland, Oregon, United States
OHSU Center for Health and Healing
🇺🇸Portland, Oregon, United States
Advanced Dermatology of the Midlands
🇺🇸Omaha, Nebraska, United States
Avance Clinical Trials Inc
🇺🇸Laguna Niguel, California, United States
Pinnacle Research Group, LLC
🇺🇸Anniston, Alabama, United States
Investigate MD
🇺🇸Scottsdale, Arizona, United States
Arkansas Research Trials
🇺🇸North Little Rock, Arkansas, United States
Burke Pharmaceutical Research
🇺🇸Hot Springs, Arkansas, United States
Johnson Dermatology
🇺🇸Fort Smith, Arkansas, United States
Northwest Arkansas Clinical Trials Center
🇺🇸Rogers, Arkansas, United States
Orange County Research Institute
🇺🇸Anaheim, California, United States
Wallace Medical Group, Inc.
🇺🇸Beverly Hills, California, United States
Hope Clinical Research, Inc.
🇺🇸Canoga Park, California, United States
Bakersfield Dermatology and Skin Cancer Medical Group
🇺🇸Bakersfield, California, United States
California Dermatology & Clinical Research Institute
🇺🇸Encinitas, California, United States
Center For Dermatology Clinical Research, Inc.
🇺🇸Fremont, California, United States
First OC Dermatology
🇺🇸Fountain Valley, California, United States
MD Studies
🇺🇸Fountain Valley, California, United States
Axon Clinical Research
🇺🇸Inglewood, California, United States
Ablon Skin Institute and Research Center
🇺🇸Manhattan Beach, California, United States
Cura Clinical Research
🇺🇸Palmdale, California, United States
MD Strategies Research Centers MDSRC
🇺🇸Poway, California, United States
Dermatology Clinical Trials
🇺🇸Newport Beach, California, United States
Therapeutics Clinical Research
🇺🇸San Diego, California, United States
Care Access Research
🇺🇸San Jose, California, United States
San Luis Dermatology & Laser Clinic
🇺🇸San Luis Obispo, California, United States
Southern California Dermatology, Inc.
🇺🇸Santa Ana, California, United States
IMMUNOe International Research Centers
🇺🇸Centennial, Colorado, United States
Asthma and Allergy Associates, PC
🇺🇸Colorado Springs, Colorado, United States
Central Connecticut Dermatology
🇺🇸Cromwell, Connecticut, United States
Medical Faculty Associates, Inc.
🇺🇸Washington, District of Columbia, United States
George Washington University Medical Center
🇺🇸Washington, District of Columbia, United States
Clinical Physiology Associates
🇺🇸Fort Myers, Florida, United States
Pediatric Skin Research, LLC
🇺🇸Coral Gables, Florida, United States
St. Francis Medical Institute
🇺🇸Clearwater, Florida, United States
Florida Academic Centers Research and Education, LLC
🇺🇸Coral Gables, Florida, United States
The Community Research of South Florida
🇺🇸Hialeah, Florida, United States
Direct Helpers Research Center
🇺🇸Hialeah, Florida, United States
Georgia Pollens Clinical Research Centers, Inc
🇺🇸Albany, Georgia, United States
GSI Clinical Research, LLC
🇺🇸Margate, Florida, United States
C & R Research Services USA
🇺🇸Miami Beach, Florida, United States
Encore Medical Research
🇺🇸Hollywood, Florida, United States
Solutions Through Advanced Research
🇺🇸Jacksonville, Florida, United States
Wellness Clinical Research
🇺🇸Miami Lakes, Florida, United States
Tory Sullivan, MD PA
🇺🇸North Miami Beach, Florida, United States
Park Avenue Dermatology
🇺🇸Orange Park, Florida, United States
Riverchase Dermatology and Cosmetic Surgery
🇺🇸Pembroke Pines, Florida, United States
IACT Health - VHC
🇺🇸Columbus, Georgia, United States
Georgia Skin & Cancer Clinic
🇺🇸Savannah, Georgia, United States
Sneeze, Wheeze, & Itch Associates LLC
🇺🇸Normal, Illinois, United States
Arlington Dermatology
🇺🇸Rolling Meadows, Illinois, United States
Northshore University Healthsystem
🇺🇸Skokie, Illinois, United States
Dundee Dermatology
🇺🇸West Dundee, Illinois, United States
The Indiana Clinical Trials Center
🇺🇸Plainfield, Indiana, United States
Kansas Medical Clinic
🇺🇸Topeka, Kansas, United States
Epiphany Dermatology of Kansas, LLC
🇺🇸Overland Park, Kansas, United States
Kansas Medical Clinic, an Elligo Health Research, Inc.
🇺🇸Shawnee Mission, Kansas, United States
Dermatology and Skin Cancer Specialists, LLC
🇺🇸Rockville, Maryland, United States
ActivMed Practices and Research
🇺🇸Beverly, Massachusetts, United States
Beacon Clinical Research, LLC
🇺🇸Quincy, Massachusetts, United States
Metro Boston Clinical Partners
🇺🇸Brighton, Massachusetts, United States
Oakland Dermatology
🇺🇸Auburn Hills, Michigan, United States
Great Lakes Research Group, Inc.
🇺🇸Bay City, Michigan, United States
Associated Skin Care Specialists
🇺🇸New Brighton, Minnesota, United States
Michigan Center for Research Company
🇺🇸Clarkston, Michigan, United States
St Joseph Dermatology and Vein Clinic
🇺🇸Saint Joseph, Michigan, United States
Psoriasis Treatment Center of Central New Jersey
🇺🇸East Windsor, New Jersey, United States
ALLCUTIS Research
🇺🇸Portsmouth, New Hampshire, United States
Central Dermatology PC
🇺🇸Saint Louis, Missouri, United States
MediSearch Clinical Trials
🇺🇸Saint Joseph, Missouri, United States
OnSite Clinical Solutions
🇺🇸Charlotte, North Carolina, United States
Forest Hills Dermatology Group
🇺🇸Kew Gardens, New York, United States
JUVA Skin & Laser Center
🇺🇸New York, New York, United States
Advanced Asthma and Allergy
🇺🇸Watertown, New York, United States
Icahn Sch of Med at Mt. Sinai
🇺🇸New York, New York, United States
Sadick Research Group
🇺🇸New York, New York, United States
Medication Management
🇺🇸Greensboro, North Carolina, United States
Wilmington Dermatology Center
🇺🇸Wilmington, North Carolina, United States
Ohio Pediatric Research Association
🇺🇸Dayton, Ohio, United States
Central States Research
🇺🇸Tulsa, Oklahoma, United States
Crisor, LLC, Medford office
🇺🇸Medford, Oregon, United States
The Pennsylvania Centre for Dermatology, LLC
🇺🇸Exton, Pennsylvania, United States
DermDox Dermatology Centers
🇺🇸Sugarloaf, Pennsylvania, United States
Peak Research LLC
🇺🇸Upper Saint Clair, Pennsylvania, United States
Clinical Partners, LLC
🇺🇸Johnston, Rhode Island, United States
AAPRI Clinical Research Institute
🇺🇸Warwick, Rhode Island, United States
Palmetto Clinical Trial Services, LLC
🇺🇸Anderson, South Carolina, United States
Rivergate Dermatology Clinical Research Center PL
🇺🇸Goodlettsville, Tennessee, United States
Dermatology Treatment and Research Center
🇺🇸Dallas, Texas, United States
Bellaire Dermatology Associates
🇺🇸Bellaire, Texas, United States
Austin Institute for Clinical Research
🇺🇸Pflugerville, Texas, United States
Suzanne Bruce and Associates, PA
🇺🇸Houston, Texas, United States
Center for Clinical Studies
🇺🇸Webster, Texas, United States
Cutis Wellness Dermatology
🇺🇸Laredo, Texas, United States
Progressive Clinical Research
🇺🇸San Antonio, Texas, United States
Laredo Dermatology Associates P.A.
🇺🇸Laredo, Texas, United States
Texas Dermatology and Laser Specialists
🇺🇸San Antonio, Texas, United States
Acclaim Dermatology PLLC
🇺🇸Sugar Land, Texas, United States
Velocity Clinical Research - Woseth Dermatology
🇺🇸Salt Lake City, Utah, United States
Virginia Clinical Research, Inc.
🇺🇸Norfolk, Virginia, United States
University of Utah MidValley Dematology
🇺🇸Murray, Utah, United States
Jordan Valley Dermatology Center
🇺🇸West Jordan, Utah, United States
PI-Coor Clinical Research, LLC
🇺🇸Burke, Virginia, United States
Premier Clinical Research
🇺🇸Spokane, Washington, United States
Woden Dermatology
🇦🇺Phillip, Australian Capital Territory, Australia
The Skin Hospital
🇦🇺Darlinghurst, New South Wales, Australia
Premier Specialists Pty Ltd
🇦🇺Kogarah, New South Wales, Australia
The St. George Hospital
🇦🇺Kogarah, New South Wales, Australia
Holdsworth House Medical Practice
🇦🇺Sydney, New South Wales, Australia
Skin & Cancer Foundation Australia
🇦🇺Westmead, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
The Skin Centre
🇦🇺Benowa, Queensland, Australia
University of the Sunshine Coast Clinical Trial Centre
🇦🇺Sippy Downs, Queensland, Australia
Veracity Clinical Research Pty Ltd
🇦🇺Woolloongabba, Queensland, Australia
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
Clinical Trials SA Pty Ltd
🇦🇺Hectorville, South Australia, Australia
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Skin Health Institute Inc.
🇦🇺Carlton, Victoria, Australia
Sinclair Dermatology
🇦🇺Melbourne, Victoria, Australia
Captain Stirling Medical Centre
🇦🇺Nedlands, Australia
Royal Children's Hospital
🇦🇺Parkville, Victoria, Australia
DCC Sveti Georgi
🇧🇬Haskovo, Bulgaria
Fremantle Dermatology
🇦🇺Fremantle, Western Australia, Australia
Diagnostic and Consultation Center 14
🇧🇬Sofia, Bulgaria
Alexandrovska University Hospital
🇧🇬Sofia, Bulgaria
Euro Derma clinic
🇧🇬Sofia, Bulgaria
Military Medical Academy
🇧🇬Sofia, Bulgaria
Medical centre Alitera-Med EOOD
🇧🇬Sofia, Bulgaria
University of British Columbia
🇨🇦Vancouver, British Columbia, Canada
Dermatology Research Institute
🇨🇦Calgary, Alberta, Canada
CARe Clinic
🇨🇦Red Deer, Alberta, Canada
Dr. Chih-ho Hong Medical Inc.
🇨🇦Surrey, British Columbia, Canada
Enverus Medical Research
🇨🇦Surrey, British Columbia, Canada
CCA Medical Research
🇨🇦Ajax, Ontario, Canada
Simcoderm Medical & Surgical Dermatology Centre
🇨🇦Barrie, Ontario, Canada
Skin Health
🇨🇦Peterborough, Ontario, Canada
Lynderm Research Inc.
🇨🇦Markham, Ontario, Canada
Ottawa Allergy Research Corp
🇨🇦Ottawa, Ontario, Canada
North York Research Inc.
🇨🇦North York, Ontario, Canada
The Centre for Clinical Trials, Inc
🇨🇦Oakville, Ontario, Canada
Dermatology Ottawa Research Centre
🇨🇦Ottawa, Ontario, Canada
The Centre for Dermatology
🇨🇦Richmond Hill, Ontario, Canada
International Dermatology Research
🇨🇦Montréal, Quebec, Canada
Vahlberg & Pild OU
🇪🇪Talinn, Estonia
K. Papp Clinical Research
🇨🇦Waterloo, Ontario, Canada
Kliiniliste uuringute Keskus OU
🇪🇪Tartu, Estonia
CHU de Bordeaux Hop St ANDRE
🇫🇷Bordeaux, Gironde, France
Hopital Saint Louis
🇫🇷Paris, France
CHRU de Brest - Hôpital Morvan
🇫🇷Brest, France
CHU Dijonon
🇫🇷Dijon, France
CHD Vendee
🇫🇷La Roche sur Yon, France
Cabinet Médical
🇫🇷Martigues, France
Tartu University Hospital
🇪🇪Tartu, Estonia
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
🇫🇷Nantes, France
CHU de Nice Hopital de L'Archet
🇫🇷Nice, France
Hopital Larrey
🇫🇷Toulouse cedex 9, France
Studienzentrum Dr.Beate Schwarz
🇩🇪Langenau, Baden-Württemberg, Germany
Rosenpark Research GmbH
🇩🇪Darmstadt, Hessen, Germany
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
🇩🇪Frankfurt, Hesse, Germany
Hautarztpraxis am Löwenmarkt
🇩🇪Stuttgart, Baden-Württemberg, Germany
Klinische Forschung Osnabrück
🇩🇪Osnabrück, Lower Saxony, Germany
Dermazentrum Augsburg
🇩🇪Augsburg, Bayern, Germany
Fachklinik Bad Bentheim
🇩🇪Bad Bentheim, Niedersachsen, Germany
Elbe Klinikum Buxtehude
🇩🇪Buxtehude, Niedersachsen, Germany
Hautzentrum im Jahrhunderthaus
🇩🇪Bochum, Nordrhein-Westfalen, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus
🇩🇪Münster, Nordrhein-Westfalen, Germany
Company for Medical Study & Service Selters GmbH
🇩🇪Selters, Rheinland-Pfalz, Germany
Hautarztpraxis Dr. Gerlach
🇩🇪Dresden, Sachsen, Germany
Universität Leipzig - Universitätsklinikum
🇩🇪Leipzig, Sachsen, Germany
Charité Campus Virchow-Klinikum
🇩🇪Berlin, Germany
Technische Universitaet Dresden - Universitaetsklinikum Carl Gustav Carus - Klinik und Poliklinik fuer
🇩🇪Dresden, Saxony, Germany
Velocity Clinical Research Leipzig GmbH
🇩🇪Leipzig, Saxony, Germany
SRH Wald-Klinikum Gera
🇩🇪Gera, Thüringen, Germany
Praxis Dr. med. Virgil-Oreste Mihaescu Facharzt fr Dermatologie und STD
🇩🇪Augsburg, Germany
ISA GmbH
🇩🇪Berlin, Germany
Praxis für Ganzheitliche Dermatologie im Ärztehaus
🇩🇪Berlin, Germany
Dermatologikum Hamburg
🇩🇪Hamburg, Germany
TFS Trial Support Form GmbH
🇩🇪Hamburg, Germany
Pusan National University Hospital
🇰🇷Busan, Korea, Korea, Republic of
Hanyang University Medical Center
🇰🇷Seoul, Korea, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Soon Chun Hyang University Bucheon Hospital
🇰🇷Bucheon, Gyeonggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Korea University Ansan Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Incheon St. Mary's Hospital
🇰🇷Incheon, Korea, Republic of
Clinic of Dermatology and STD
🇱🇻Riga, Latvia
JSC "CD8 Alergology Clinic"
🇱🇹Kaunas, Lithuania
Hospital of Lithuanian University of Health Sciences Kauno klinikos
🇱🇹Kaunas, Lithuania
Children's Hospital, Affiliate of Vilnius University Hospital Santaros klinikos
🇱🇹Vilnius, Lithuania
Health and Aesthetics LTD
🇱🇻Riga, Latvia
Latvian Dermatology Institute
🇱🇻Riga, Latvia
Health Center 4, Affiliate Diagnostic Center
🇱🇻Riga, Latvia
Smite Aija - Doctor Practice in Dermatology Venereology
🇱🇻Talsi, Latvia
Jsc Renmeda
🇱🇹Vilnius, Lithuania
JSC "Center for Diagnosis and Treatment of Allergic Diseases"
🇱🇹Vilnius, Lithuania
JSC Inlita (Santaros CTC)
🇱🇹Vilnius, Lithuania
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
Hospital Infantil de Mexico Federico Gomez
🇲🇽Ciudad de Mexico, Federal District, Mexico
Diamond Clinic
🇵🇱Krakow, Malopolskie, Poland
Centrum Medyczne Evimed
🇵🇱Warsaw, Mazowieckie, Poland
Grupo Clinico CATEI Sociedad Civil
🇲🇽Guadalajara, Jalisco, Mexico
Clinica De Enfermedades Cronicas y Procedimientos Especiales
🇲🇽Morelia, Michoacan, Mexico
Cemdeicy S.C.P.
🇲🇽Merida, Yucatán, Mexico
Derma Norte del Bajio
🇲🇽Aguascalientes, Mexico
Arke Estudios Clinicos S.A. de C.V.
🇲🇽Veracruz, Mexico
dermMedica Sp. z o.o.
🇵🇱Wrocław, Dolnośląskie, Poland
Dermoklinika Centrum Medyczne s.c. M. Kierstan J. Narbutt A. Lesiak
🇵🇱Lodz, Lodzkie, Poland
Grazyna Pulka Specjalistyczny Osrodek "ALL-MED"
🇵🇱Krakow, Malopolskie, Poland
Centralny Szpital Kliniczny MSWiA
🇵🇱Warszawa, Mazowieckie, Poland
Labderm s.c.
🇵🇱Ossy, Slaskie, Poland
Clinica Vitae Sp. z o.o.
🇵🇱Gdansk, Woj. Pomorskie, Poland
Zespol Naukowo - Leczniczy "Iwolang" Sp. z o.o.
🇵🇱Iwonicz Zdroj, Wojewodztwo Podkarpackie, Poland
Laser Clinic Dermatologia Laserowa Medycyna Estetyczna
🇵🇱Szczecin, Zachodniopomorskie, Poland
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny Anna Ploszczuk
🇵🇱Bialystok, Poland
Wojewodzki Szpital Zespolony
🇵🇱Elblag, Poland
Oddzial Dermatologii COPERNICUS
🇵🇱Gdansk, Poland
Centrum Badan Klinicznych PI-House sp. z o.o.
🇵🇱Gdynia, Poland
Holsamed
🇵🇱Katowice, Poland
Gabinet Dermatlogiczny. Beata Krecisz
🇵🇱Kielce, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie
🇵🇱Lublin, Poland
Centrum Alergologii Teresa Hofman
🇵🇱Poznan, Poland
National University Hospital
🇸🇬Singapore, Central Singapore, Singapore
Klinika Ambroziak Sp. Z.O.O.
🇵🇱Warszawa, Poland
CityClinic Przychodnia Lekarsko-Psychologiczna
🇵🇱Wroclaw, Poland
Centrum Medyczne Angelius Provita
🇵🇱Katowice, Śląskie, Poland
Kliniczny Szpital Wojewodzki nr. 1 Klinika Dermatologii
🇵🇱Rzeszow, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Alergo-Med Specjalistyczna Przychodnia Lekarska Sp Z O.O.
🇵🇱Tarnow, Poland
Clinical Research Group Sp. z o.o.
🇵🇱Warszawa, Poland
High-Med Prywatny Gabinet Lekarski
🇵🇱Warszawa, Poland
MTZ Clinical Research Sp.z.o.o.
🇵🇱Warszawa, Poland
Singapore General Hospital
🇸🇬Singapore, Singapore
Kk Women'S and Childrens Hospital
🇸🇬Singapore, Singapore
National Skin Centre NSC
🇸🇬Singapore, Singapore
Hospital Sant Joan de Déu
🇪🇸Esplugues de Llobregat, Barcelona [Barcelona], Spain
Hospital Germans Trias i Pujol
🇪🇸Badalona, Catalunya [Cataluña], Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario Basurto
🇪🇸Bilbao (Bizkaia), Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Niaosong, Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Taipei Medical University Shuang Ho Hospital
🇨🇳New Taipei, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital - Linkou
🇨🇳Taoyuan City, Taiwan
Community Institution Zaporizhzhya Regional Dermatovenereology Clinical Hospital of Zaporizhzhya Regional Council
🇺🇦Poshtova Square 2, Zaporizhzhya, Ukraine
Municipal Healthcare Institution Kharkiv City Dermatoverenologic Dispensary N2
🇺🇦Kharkiv, Ukraine
SE "Institute of Dermatology and Venerology of NAMS of Ukraine"
🇺🇦Kharkiv, Ukraine
Rivne Regional Dermatology and Venereology Dispensary
🇺🇦Rivne, Ukraine
Treatment-diagnostic center PE "Asclepius"
🇺🇦Uzhhorod, Ukraine
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
Innovate Research, LLC
🇺🇸Fort Worth, Texas, United States
Wiseman Dermatology Research Inc.
🇨🇦Winnipeg, Manitoba, Canada
Sunwise Clinical Research
🇺🇸Lafayette, California, United States
Marietta Dermatology Clinical Research
🇺🇸Marietta, Georgia, United States
Arlington Research Center, Inc
🇺🇸Arlington, Texas, United States
Integrative Skin Science and Research
🇺🇸Sacramento, California, United States
ForCare Clinical Research
🇺🇸Tampa, Florida, United States
Olympian Clinical Research
🇺🇸Tampa, Florida, United States
Skin Sciences, PLLC
🇺🇸Louisville, Kentucky, United States
University of South Florida College of Medicine
🇺🇸Tampa, Florida, United States
Fivenson Dermatology
🇺🇸Ann Arbor, Michigan, United States
Meridian Clinical Research
🇺🇸Baton Rouge, Louisiana, United States
Skin Laser and Surgery Specialists, a Division of Schweiger Dermatology
🇺🇸Hackensack, New Jersey, United States
Wake Research Associates
🇺🇸Raleigh, North Carolina, United States
Vital Prospects Clinical Research Institute, PC
🇺🇸Tulsa, Oklahoma, United States
Clinical Research Center of the Carolinas
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Tulane Univ School of Med
🇺🇸New Orleans, Louisiana, United States
The University of Florida Health System
🇺🇸Gainesville, Florida, United States
Burswood Dermatology
🇦🇺Victoria Park, Western Australia, Australia
Advanced Medical Research
🇺🇸Sandy Springs, Georgia, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States