Gastric pH in Critically Ill Patients
Phase 4
Completed
- Conditions
- Critically Ill PatientsIndication for Stress Ulcer Prophylaxis
- Interventions
- Registration Number
- NCT00590928
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and in healing gastric acid-dependent diseases. It is unknown, whether proton pump inhibitors are more effective in increasing gastric pH than H2-receptor antagonists in critically ill patients requiring stress ulcer prophylaxis.
- Detailed Description
Gastric pH is measured continuously for 72 hours with a pipolar microelectrode placed between 7 and 15cm below the lower esophageal sphincter.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
- critically ill patients
- indication for stress ulcer prophylaxis
- gastric pH < 4
Exclusion Criteria
- gastrointestinal bleeding
- gastric pH > 4
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 esomeprazole patients with indication for stress ulcer prophylaxis and gastric pH \< 4 2 ranitidine patients with indication for stress ulcer prophylaxis and gastric pH \< 4
- Primary Outcome Measures
Name Time Method the percentage of time with gastric pH > 4 72 hours
- Secondary Outcome Measures
Name Time Method median gastric pH 72 hours incidence of gastrointestinal bleeding 72 hours incidence of ventilator associated pneumonia ICU stay the percentage of time with an gastric pH > 5 72 hours
Trial Locations
- Locations (1)
Medical University of Vienna, Department of Medicine III, ICU
🇦🇹Vienna, Austria