Behavioral Activation for Treatment of Depression in Adolescents With Autism Spectrum Disorder: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Children's Depression Inventory, Second Edition, Parent Report
研究概览
简要总结
In this study, the investigators will examine the feasibility, acceptability, and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in adolescents with autism spectrum disorder or ASD (i.e., Behavioral Activation for Adolescents with ASD, BA-A).
详细描述
In this study, the investigators will examine the feasibility, acceptability, and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in adolescents with ASD (i.e., Behavioral Activation for Adolescents with ASD, BA-A). BA-A is a 12-session manualized treatment that utilizes established behavioral activation strategies and incorporates common mental health treatment adaptations for young people with ASD. For this project, the investigators will pilot BA-A with 23 adolescents (12-17 years of age) with ASD and clinically significant depression symptoms. To investigate BA-A feasibility, the investigators will examine treatment session attendance and therapist treatment fidelity. To investigate BA-A acceptability, the investigators will utilize a mixed methods approach, inclusive of surveys and qualitative interviews, to inform BA-A protocol refinement. To investigate BA-A preliminary efficacy, the investigators will examine depression symptoms, as well as secondary outcome measures, at pre-treatment, post-treatment, and one-month follow-up.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Previous diagnosis of ASD by a qualified health care provider
- •Children's Depression Inventory, Second Edition (CDI2) parent-report and/or self-report T- score ≥ 65
- •Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II) Full Scale IQ, Two-Subtest Form (FSIQ-2) ≥ 85
- •Participation of a parent or legal guardian living in the same home who can read and write in English at or above the fifth grade level
- •Teens must have been on a stable dose of medications for mood, anxiety, or behavior for at least three months prior to enrollment and have no planned medication changes during study period
- •Not actively participating in another psychotherapy during study period
排除标准
- •High suicide risk
- •Physical aggression
- •Psychotic and/or manic symptoms
结局指标
主要结局
Children's Depression Inventory, Second Edition, Parent Report
时间窗: Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment
Children's Depression Inventory, Second Edition, Self Report
时间窗: Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment
Children's Depression Rating Scale, Revised
时间窗: Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment
次要结局
- Social Skills Improvement System, Parent Report(Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment)
- Spence Children's Anxiety Scale, Self Report(Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment)
- Spence Children's Anxiety Scale, Parent Report(Change from pre-treatment to post-treatment (i.e., within one week of finishing 12-week treatment) and one-month following treatment)
研究者
Micah Mazurek
Novartis U.S. Foundation Professor of Education
University of Virginia