Epidemiology of Acute Self-poisoning in Emergency Services in France

Completed

• Conditions: Suicide Attempts

• Registration Number: NCT02518386
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Acute self poisoning is a leading cause of suicide attempts and leads to frequent emergency department visits. However, the exact epidemiology of acute self poisoning is not known. The description of the clinical pathway and the characteristics of patients with acute self poisoning could lead to an improvement in emergency care.

The Investigators will conduct a 48h observational study in emergency services in France. Investigators primary objective is to gathered epidemiological clinical and treatment data during emergency dispatch, prehospital care and inhospital emergency care.

Detailed Description

Acute self poisoned patients will be prospectively and anonymously recruited by emergency physicians in charge during two days. Acute self poisoning is define as follow: intentional medicine intake in the 24h hours before emergency department admission.

Epidemiological, clinical, toxicological and treatment data will be gathered. Outcome of patient will be prospectively assessed at 30days.

All data will be transmitted to the principal investigators. Then, 20% of the data will be monitored by an independent committee.

Exhaustivity will be retrospectively assessed by the number of inclusions in 10 emergency centers divided by the total number of possible inclusions in these centers.

Finally, an independent statistician will be in charge of the analysis.

Study Timeline

• Study First Submitted: 2015-02-24
• Study Start: 2015-03
• Primary Completion: 2015-04
• Study First Submitted QC: 2015-08-04
• Study First Posted: 2015-08-07
• Study Completion: 2016-06
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-16
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

• acute self poisoning defined as the intentional intake (oral, nasal, injection etc.) of medicines during the 24h before first medical contact

Exclusion Criteria

• cardiac arrest at first medical contact (dispatch or physician)
• acute self poisoning without any medication intake
• non intentional poisoning

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of each drug class	48h

Secondary Outcome Measures

Name	Time	Method
prehospital and inhospital mortality	30 days
icu admission (percentage)	48h
odds ratio of drug classes according to sexe and age	48h
number of participants with poisoning incident	48h
percentage of each antidotal treatment	48h
Time (median) of admission according unit of admission	48h
mobile intensive care unit (percentage) dispatch	30 days
Age according to drug classes ingestion	48h	Median age compared according drug classes ingestion
Gender according to drug classes ingestion	48h	Pourcentage of gender compared according drug classes ingestion
Time (median) of admission according to drug classes ingestion	48h
Mortality according to drug class ingestion	30 days
ICU admission according to drug class ingestion	30 days
percentage of errors according to the Grenoble clinical decision rule	30 days
multivariate analysis to describe factors associated with ICU admission	30 days
multivariate analysis to describe factors associated with mobile intensive care unit dispatch	30 days