Evaluation of the Epidemiology and the Take Load of Voluntary Drug Intoxications by the Emergency Structures in France
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 700
- 主要终点
- Percentage of each drug class
研究概览
简要总结
Acute self poisoning is a leading cause of suicide attempts and leads to frequent emergency department visits. However, the exact epidemiology of acute self poisoning is not known. The description of the clinical pathway and the characteristics of patients with acute self poisoning could lead to an improvement in emergency care.
The Investigators will conduct a 48h observational study in emergency services in France. Investigators primary objective is to gathered epidemiological clinical and treatment data during emergency dispatch, prehospital care and inhospital emergency care.
详细描述
Acute self poisoned patients will be prospectively and anonymously recruited by emergency physicians in charge during two days. Acute self poisoning is define as follow: intentional medicine intake in the 24h hours before emergency department admission.
Epidemiological, clinical, toxicological and treatment data will be gathered. Outcome of patient will be prospectively assessed at 30days.
All data will be transmitted to the principal investigators. Then, 20% of the data will be monitored by an independent committee.
Exhaustivity will be retrospectively assessed by the number of inclusions in 10 emergency centers divided by the total number of possible inclusions in these centers.
Finally, an independent statistician will be in charge of the analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute self poisoning defined as the intentional intake (oral, nasal, injection etc.) of medicines during the 24h before first medical contact
排除标准
- •cardiac arrest at first medical contact (dispatch or physician)
- •acute self poisoning without any medication intake
- •non intentional poisoning
结局指标
主要结局
Percentage of each drug class
时间窗: 48h
次要结局
- percentage of errors according to the Grenoble clinical decision rule(30 days)
- multivariate analysis to describe factors associated with ICU admission(30 days)
- multivariate analysis to describe factors associated with mobile intensive care unit dispatch(30 days)
- odds ratio of drug classes according to sexe and age(48h)
- number of participants with poisoning incident(48h)
- prehospital and inhospital mortality(30 days)
- percentage of each antidotal treatment(48h)
- Time (median) of admission according unit of admission(48h)
- mobile intensive care unit (percentage) dispatch(30 days)
- Age according to drug classes ingestion(48h)
- Gender according to drug classes ingestion(48h)
- Time (median) of admission according to drug classes ingestion(48h)
- Mortality according to drug class ingestion(30 days)
- ICU admission according to drug class ingestion(30 days)
- icu admission (percentage)(48h)