Body Weight and Carb Metabolism
- Conditions
- Exercise Metabolism
- Interventions
- Other: Moderate-intensity (relative) exercise with glucose ingestionOther: Moderate-intensity (absolute) exercise with glucose ingestion
- Registration Number
- NCT05330481
- Lead Sponsor
- University of Bath
- Brief Summary
Whilst theoretically, body size should influence the capacity for intestinal carbohydrate absorption and thus exogenous oxidation rates during exercise, there is currently little empirical evidence to support this hypothesis. Accordingly, current nutrition guidelines for carbohydrate intake during exercise do not take body mass into account. Therefore, there is a need to establish whether body mass is related to exogenous carbohydrate oxidation rates during exercise. If such a relationship is established, this would lay the foundation to revise the current sports nutrition guidelines regarding carbohydrate intake during exercise.
The aims of this study are, therefore, to: 1) establish whether larger individuals display higher rates of exogenous carbohydrate oxidation than smaller individuals; and 2) establish if such a difference can be explained by the higher absolute exercise intensity, and thus the energy demand of exercise. It is hypothesised that larger individuals will demonstrate higher exogenous carbohydrate oxidation rates than smaller individuals, and that this difference will be partly (but not completely) diminished when the absolute intensity of exercise is matched.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Able to cycle continuously for 2 hours at a moderate intensity
- VO2max of between 40-75 mL/kg/min
- Fat-mass index (determined by dual energy x-ray absorptiometry) < 5.5 kg·m-2
- Diagnosed disorders of the gastrointestinal tract (e.g. crohn's, colitis etc.)
- People following a low-carbohydrate, high-fat diet
- Pregnant or lactating
- Diagnosed cardiovascular disease
- Possible symptoms of cardiovascular disease
- Diagnosis of diabetes of any type
- Hypercholesterolaemia (total cholesterol ≥ 6.2 mmol/L
- Hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg)
- Current smoker
- Family history of coronary artery disease (first-degree relative <60 years)
- Prevalence of vascular disease
- Autonomic neuropathy
- Kidney disease
- Diagnosed pulmonary disease (e.g. chronic obstructive pulmonary disease, asthma, interstitial lung disease or cystic fibrosis)
- Blood borne disease or infection
- Osteoporosis
- Osteoarthritis
- Blood clotting disorders
- Food intolerances/allergies (these may not specifically exclude you- please talk to the investigator)
- Sensitivity or allergy to anaesthetic
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description >70 kg body mass Moderate-intensity (relative) exercise with glucose ingestion Cyclists or triathletes with a body mass of less than 70 kg >70 kg body mass Moderate-intensity (absolute) exercise with glucose ingestion Cyclists or triathletes with a body mass of less than 70 kg <70 kg body mass Moderate-intensity (relative) exercise with glucose ingestion Cyclists or triathletes with a body mass of less than 70 kg
- Primary Outcome Measures
Name Time Method Total exogenous carbohydrate oxidation (g) minutes 30-120 of exercise Sum of exogenous carbohydrate oxidation in g
Peak exogenous carbohydrate oxidation rate (g/min) 120 minute Peak exogenous carbohydrate oxidation rate (g/min)
- Secondary Outcome Measures
Name Time Method Whole-body fat oxidation rate (g) minutes 30-120 of exercise Sum of whole-body fat oxidation (g)
Plasma lactate concentrations (mmol/L) minutes 0-120 of exercise Plasma lactate concentrations (mmol/L)
Dietary protein intake (grams/day) 72-hour food diary Dietary protein intake (grams/day)
Total exogenous carbohydrate oxidation (g/kgFFM) minutes 30-120 of exercise i Sum of exogenous carbohydrate oxidation (g/kgFFM)
Whole-body carbohydrate oxidation rate (g) minutes 30-120 of exercise Sum of whole-body carbohydrate oxidation (g)
Plasma glucose concentrations (mmol/L) minutes 0-120 of exercise Plasma glucose concentrations (mmol/L)
Whole-body carbohydrate oxidation rate (mg/kgFFM) Sum of minutes 30-120 of exercise Sum of whole-body carbohydrate oxidation (mg/kgFFM)
Whole-body fat oxidation rate (mg/kgFFM) minutes 30-120 of exercise Sum of whole-body fat oxidation (mg/kgFFM)
Dietary fat intake (grams/day) 72-hour food diary Dietary fat intake (grams/day)
Dietary fibre intake (grams/kilogram/day) 72-hour food diary Dietary fibre intake (grams/kilogram/day)
Endogenous carbohydrate oxidation rate (g) minutes 30-120 of exercise Sum of endogenous carbohydrate oxidation (g)
Endogenous carbohydrate oxidation rate (mg/kgFFM) minutes 30-120 of exercise Sum of endogenous carbohydrate oxidation (mg/kgFFM)
Plasma non-esterified fatty acid concentrations (mmol/L) minutes 0-120 of exercise Plasma non-esterified fatty acid concentrations (mmol/L)
Plasma insulin concentrations (pmol/L) minutes 0-120 of exercise Plasma insulin concentrations (pmol/L)
Dietary carbohydrate intake (grams/day) 72-hour food diary in g/d Dietary carbohydrate intake (grams/day)
Dietary sugar intake (grams/day) 72-hour food diary Dietary sugar intake (grams/day)
Dietary fibre intake (grams/day) 72-hour food diary Dietary fibre intake (grams/day)
Dietary sugar intake (grams/kilogram/day) 72-hour food diary Dietary sugar intake (grams/kilogram/day)
Dietary fat intake (grams/kilogram/day) 72-hour food diary Dietary fat intake (grams/kilogram/day)
Dietary protein intake (grams/kilogram/day) 72-hour food diary Dietary protein intake (grams/kilogram/day)
Dietary energy intake (kiloJoules/day) 72-hour food diary Dietary energy intake (kiloJoules/day)
Dietary energy intake (kilojoules/kilogram/day) 72-hour food diary Dietary energy intake (kilojoules/kilogram/day)
Dietary carbohydrate intake (grams/kilogram/day) 72-hour food diary Dietary carbohydrate intake (grams/kilogram/day)
Trial Locations
- Locations (1)
Department for Health, University of Bath
🇬🇧Bath, United Kingdom
Department for Health, University of Bath🇬🇧Bath, United Kingdom