The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- P2Y12 reaction units and Aspirin reaction units
研究概览
简要总结
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivty in patients with coronary artery disease on dual antiplatelet therapy.
详细描述
Recent landmark clinical trials on the use of colchicine in patients with chronic coronary artery disease has led to its implementation as an FDA approved drug for secondary prevention in patients with coronary artery disease. Colchicine exerts a range of anti inflammatory effects which plays a major role in reduction of atherosclerosis and prevention cardiovascular events. This current study aims to investigate the effect of colchicine on platelet reactivity in patients with stable coronary artery disease already on dual anticoagulants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with stable coronary artery disease
- •Patients older than 18 years of age.
- •Patients currently on dual anti platelets, aspirin and clopidogrel
排除标准
- •Patients already on colchicine
研究组 & 干预措施
Colchicine 0.5mg po bd
Patients with coronary disease taking Colchicine 0.5mg twice-daily orally for two weeks
干预措施: Colchicine 0.5 MG oral tablet twice daily (Drug)
结局指标
主要结局
P2Y12 reaction units and Aspirin reaction units
时间窗: two weeks
P2Y12 and Aspirin reaction units pre and post colchicine 0.5mg twice daily oral dose.
次要结局
未报告次要终点
研究者
Naveen Seecheran
Naveen Seecheran
The University of The West Indies