A randomised, controlled trial to assess the feasibility of consuming three dietary oils over 3 months amongst osteoarthritis patients

The Queen Elizabeth Hospital0 sites30 target enrollmentSeptember 12, 2019

Overview

No summary available.

Registry

who.int

Start Date

September 12, 2019

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•Clinical hand or knee OA (diagnosed by a medical professional)
•40 years of age or above
•Able and willing to consume up to 18 ml of high monounsaturated liquid oil per day for 12 weeks (olive oil and canola oil), or to consume 1x1500 mg fish oil capsule daily for 12 weeks
•Able to commit to study for 3 months, including not altering diet or physical activity levels.
•English literate, for the purpose of questionnaire completion and protocol comprehension
•Body mass index (BMI) greater than 35 kg/m2\. Because there is a small risk of weight gain anyone with a BMI over 35 will be excluded.

•Allergy to seafood
•Allergy or intolerance to olive oil and canola oil
•On waiting list for total knee replacement/major hand surgery
•Other major medical treatment or planned surgery in the next 3 months
•Known cardiovascular disease, cognitive disease, kidney or liver disease, cancer diagnosis within the last 6 months
•When not managed with medications: type 2 diabetes (fasting blood glucose greater than or equal to 7\.0 mmol/L or greater than 11\.0 mmol/L non\-fasting, and HbA1c greater than or equal to 6\.5%), hypertension (BP \>139 SBP or \>89 DBP) or hypercholesterolemia (total cholesterol \>5\.5 mmol/L)
•Otherwise medically unfit, at investigator discretion
•BMI of 36 kg/m2 or greater
•Taking anticoagulants (e.g. warfarin etc)