Functional Immuno-monitoring of Cystic Fibrosis Patients
Recruiting
- Conditions
- E84Cystic fibrosis
- Registration Number
- DRKS00023486
- Lead Sponsor
- Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Age at least 18 years; indication for Kaftrio therapy; homozygous deltaF508 mutation or compound heterozygous for deltaF508 and a minimal function mutation
Exclusion Criteria
acute infection, fever or surgical intervention within the last 7 days; blood transfusion within the last 3 months; immunosuppressive therapy; systemic antibiotic therapy within the last 3 days
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method experimental parameters of neutrophil function <br>timepoints: before start of CFTR modulator therapy and 6 months afterwards<br>methods: flow cytometry
- Secondary Outcome Measures
Name Time Method lung function parameters<br>timepoints: before start of CFTR modulator therapy and 6 months afterwards<br>methods: spirometry