Functionality of the Migraine Brain; a prospective fMRI study

Completed

• Conditions: headache; Migraine; 10019231

• Registration Number: NL-OMON35187
• Lead Sponsor: eurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Migraineurs
Inclusion criteria; i) Female migraine patients, suffering from menstrually related migraine according to IHS criteria; ii) in total, 1-2 attacks of migraine per month; iii) aged between 18-50 years; iv) provided written informed consent; v) preferable, no use of acute anti migraine medication during the study* and vi) a regular menstrual cyclus.;Healthy controls
Inclusion criteria; i) Having a regular menstrual cycle; ii) aged between 18-50 years; iii) provided written informed consent;

Exclusion Criteria

Migraineurs
i) other neurological or psychiatric disease; ii) contraindications for being in a MR-scanner; iii) use of medications that may influence brain functioning (antidepressants; sedatives); iv) use of prophylactic antimigaine medication; v) presence of premenstrual syndrome; vi) having undergone procedures that influence regularity of menstrual cyclus, such as ovariectomy and hysterectomy; and vii) use of (oral) contraceptives.;Healthy controls
i) any neurological or psychiatric disease, including primary headache syndrome; ii) headache prior to menstrual flow; iii) contraindications for being in a MR-scanner; iv) use of medications that may influence brain functioning (antidepressants; sedatives); v) symptoms of premenstrual syndrome; vi) having undergone procedures that influence regularity of menstrual cyclus, such as ovariectomy and hysterectomy; vii) using medication that is also prescribed for migraine prophylaxis (ß-blokkers etc.), and viii) use of (oral) contraceptives.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcome parameters:<br /><br><br /><br>- MR: RSN measurements: Time-dependent changes in neuronal activity as<br /><br>reflected by the BOLD signal in several functional networks;<br /><br>Time-dependent changes in regions; (voxel-wise) functional connectivity.<br /><br>- Cognitive tests: results of global-local task<br /><br>- Venapuncture: levels of female hormones (LH, FSH, oestrogen)<br /><br>- Questionnaires: information on presence/ absence of premonitory symptoms and<br /><br>headache</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a. </p><br>