Efficacy of Trichloroacetic Acid in Patients of Alopecia Areata : Clinico-histopathological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Mac Donald Hull and Norris grading system
研究概览
简要总结
Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss.
Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.
详细描述
For each patient the following will be done :
- History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ).
- All patients will give a written, informed consent for induction.
- Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55).
- Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart.
- serial photographs and dermoscopic examination every month will be done and patient will be score.
- Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair.
- histopathological examination will be done before the first session and one month after third session.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Alopecia areata multilocularis and alopecia totalis. Age from 16-60 years old. Ophiasis pattern alopecia areata.
排除标准
- •Age less than 16 and more than 60years old. Alopecia areata of the face.
- •Patient under treatment.
研究组 & 干预措施
single group
Trichloroacetic acid
干预措施: Trichloroacetic acid (Drug)
结局指标
主要结局
Mac Donald Hull and Norris grading system
时间窗: 4 weeks after the end of treatment
regrowth of vellus hair, regrowth of sparse pigmented terminal hair, regrowth of terminal hair with patches of alopecia and regrowth of terminal hair on scalp.
trichoscopic parameters
时间窗: after each session and 4 weeks after the end of treatment
determine exclamation mark hairs, black dots, yellow dots and broken hairs
Scoring for density of hair regrowth
时间窗: after each session and 4 weeks after the end of treatment
No hair growth, 1%-25% growth, 26%-50% growth, 51%-75% growth and 76%-100% growth
Scoring of texture of regrown hair
时间窗: after each session and 4 weeks after the end of treatment
Fine vellus hair, Intermediate hair,Normal coarse hair
Scoring of pigmentation of regrown hair
时间窗: after each session and 4 weeks after the end of treatment
Partially pigmented, Moderately pigmented, Normally pigmented
histopathological changes
时间窗: after each session and 4 weeks after the end of treatment
appearance of lymphocytes around hair follicle, appearance of new blood vessels and size of thickness of hair follicles
Scoring of overall response at the end of the study
时间窗: after each session and 4 weeks after the end of treatment
No response, Minimal response, Moderate response, Good response and Excellent response
次要结局
未报告次要终点
研究者
Hossam Mamdouh Anter Esmail
Assisstant lecturer of dermatology,venerology and andrology
Al-Azhar University