New Treatment of Alopecia Areata

Not Applicable

Completed

• Conditions: Alopecia Areata
• Interventions: Drug: Trichloroacetic acid

• Registration Number: NCT05594316
• Lead Sponsor: Al-Azhar University

Brief Summary

Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss.

Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.

Detailed Description

For each patient the following will be done :

1. History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ).

2. All patients will give a written, informed consent for induction.

3. Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55).

4. Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart.

5. serial photographs and dermoscopic examination every month will be done and patient will be score.

6. Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair.

7. histopathological examination will be done before the first session and one month after third session.

Study Timeline

• Study Start: 2019-05-01
• Primary Completion: 2022-08-01
• Status Verified: 2022-10
• Study Completion: 2022-10-19
• Study First Submitted: 2022-10-19
• Study First Submitted QC: 2022-10-21
• Last Update Submitted: 2022-10-21
• Study First Posted: 2022-10-26
• Last Update Posted: 2022-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Alopecia areata multilocularis and alopecia totalis. Age from 16-60 years old. Ophiasis pattern alopecia areata.

Exclusion Criteria

• Age less than 16 and more than 60years old. Alopecia areata of the face.
• Patient under treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
single group	Trichloroacetic acid	Trichloroacetic acid

Primary Outcome Measures

Name	Time	Method
Mac Donald Hull and Norris grading system	4 weeks after the end of treatment	regrowth of vellus hair, regrowth of sparse pigmented terminal hair, regrowth of terminal hair with patches of alopecia and regrowth of terminal hair on scalp.
trichoscopic parameters	after each session and 4 weeks after the end of treatment	determine exclamation mark hairs, black dots, yellow dots and broken hairs
Scoring for density of hair regrowth	after each session and 4 weeks after the end of treatment	No hair growth, 1%-25% growth, 26%-50% growth, 51%-75% growth and 76%-100% growth
Scoring of texture of regrown hair	after each session and 4 weeks after the end of treatment	Fine vellus hair, Intermediate hair,Normal coarse hair
Scoring of pigmentation of regrown hair	after each session and 4 weeks after the end of treatment	Partially pigmented, Moderately pigmented, Normally pigmented
histopathological changes	after each session and 4 weeks after the end of treatment	appearance of lymphocytes around hair follicle, appearance of new blood vessels and size of thickness of hair follicles
Scoring of overall response at the end of the study	after each session and 4 weeks after the end of treatment	No response, Minimal response, Moderate response, Good response and Excellent response

Trial Locations

Locations (2)

Al-Azhar university, faculty of medicine; 🇪🇬 Cairo, Egypt

Al-Azhar university; 🇪🇬 Cairo, Egypt