Safety and feasibility of neural transplantation in early to moderate Huntington's disease in the UK
Not Applicable
Completed
- Conditions
- euroscience, psychiatryMental and Behavioural DisordersHuntington's disease
- Registration Number
- ISRCTN36485475
- Lead Sponsor
- Medical Research Council (UK)
- Brief Summary
1. 2002 results in http://www.ncbi.nlm.nih.gov/pubmed/12438470 2. 2013 results in www.ncbi.nlm.nih.gov/pubmed/23345280 3. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30286516 (added 27/08/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 17
Inclusion Criteria
1. Genetically confirmed Huntington's disease
2. Early to moderate stage of disease
3. Presence of motor signs
4. Availability of one close primary informant
Exclusion Criteria
1. Advanced disease
2. Still employable in usual occupation
3. Other concurrent major illness
4. Current serious psychiatric disturbance
5. Inadequate social support
6. Below the age of 18
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Safety trial:<br> 1. Presence/absence of adverse events<br> 2. Feasibility:<br> a. co-ordination of an effective and efficient programme for foetal tissue collection<br> b. biosafety assessment<br> c. preparation and implantation into identified patients and their long term evaluation on the relevant structural and functional criteria of graft survival and efficacy<br><br> Efficacy trial:<br> Retardation or reversal of the progress of the disease in the affected patients as determined by the neurological, neuropsychological and neuropsychiatric and imaging criteria of neuropsychological tests of cognition using the CAmbridge Neuropsychological Test Automated Battery (CANTAB) test battery.<br>
- Secondary Outcome Measures
Name Time Method o secondary outcome measures