ULTRA-HYPO Fractionated (UHF) Compared to Moderate-HYPO Fractionated (MHF) Prostate IGRT With HDR Brachytherapy BOOST : A Phase 1-2 Study.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prostate Cancer
- Sponsor
- CHU de Quebec-Universite Laval
- Enrollment
- 205
- Locations
- 1
- Primary Endpoint
- urinary toxicity analysis (IPSS)
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
Phase 1-2 study, comparing ultra-hypofractionnated (UH) to a moderately hypofractionnated (MH) radiation therapy, with image guided HDR prostate brachytherapy. Using iso-equivalent doses, a non-inferiority analysis will be done in order to prove UH non-inferior to MH, toxicity wise. Acceptability, tolerability, acute and late toxicity will be reported. MRI visible dominant intra-prostatic lesion will be outlines and variability between radiation oncologists and radiologists will be reported. As secondary objective, biochemical and clinical failure free survival will be reported at 5 & 10 years.
Detailed Description
Phase 1 : consists in a feasibility study (First 28 patients). Phase 2 : monocentric prospective comparative cohort study. Recruitment : * "Centre intégré de cancérologie du CHU de Québec-Université Laval." * Recruitment period: December 2015 to June 2023 Brachytherapy : * Implantation under general or spinal anesthesia * Foley catheter insertion in bladder. * TRUS prostate localisation. * Prostate volume measurement. * Gold fiducial markers (3) insertion. * Prostate brachytherapy catheters (14 à 21) insertion. * Cystoscopy for bladder and urethra integrity control. * Re-insertion of foley catheter after cystoscopy. Planning imaging: TRUS or CT scan (has needed). Structures delineation by radiation oncologist (brachytherapist). * Prostate * Seminale vesicles * Rectum * Colon sigmoïde * Bladder * Urethra * Penile bulb Dosimetric optimisation * Oncentra Prostate v. 4.2.2 d'Elekta brachytherapy (Veenendaal, The Netherlands) * Oncentra Brachy version 4.6 (if under CT scan). Treatment (brachytherapy dose delivery). * 15 Gy in one fraction * Direct interstitial dose monitoring (20 patients or more). Fiber-optic dosimeter inserted in prostate brachytherpy catheter for live dose delivery mesurements. Foley ablation under full bladder, same day or day after therapy. Radiotherapy: * Via IMRT, VMAT or SBRT technics. * Dose : 25 Gy in 5 fractions administered over a 7 days period. 2 to 3 fractions separated by 2 days, weekend break. * PTV includes prostate and the first centimeter of seminal vesicle. Simulation * one week post brachytherapy * standard has described in the department procedure manual. * maximal CT scan slice thickness : 2-3mm. * uretro-graphy done to identify urogenital sphincter. Multiparametric MRI * If no counter-indication and available, * a T2 tridimensional sequence for prostate delineation * slice thickness : 1 mm. * a diffusion weighted sequence will be done. * a DTI with tractography can be done optionally. * contrast media (gadolinium) is optional. Physique * Linac energy (between 6 MV to 18 MV). * ARC therapy technique will be used * planification softwares: Éclipse, Pinnacle or Raystation. * Portal (kV-kV) imagery will be used for marker match. * CBCT will be done at each fraction delivered. Clinical and dosimetric data will be collected prior treatment. Primary objectives : * Toxicity analysis will be quantitatively evaluated using CTCAE (v5) at 1, 2 and 5 years post-therapy, and has needed at FU visits. Kaplan-Meier statistical analysis will be used to report toxicity evolution through time. * median IPSS scores will be reported at 3, 6, 12 months and yearly (1, 2, 3, 4 et 5) post-therapy. IPSS median time to baseline return will be calculated. * IPSS urinary scores, sexual function (SHIM) and GI toxicity (CTCAE-v5) and quality of life questionnaires ( EPIC-26) will be given at 3, 6 months and yearly thereafter (1, 2, 3, 4 et 5) post-treatment. Secondary objectives : Biochemical disease-free survival has per Phoenix definition (by American Society of Radiation Oncology - ASTRO) recommendation will be reported using Kaplan-Meier analysis.
Investigators
André-Guy Martin
Clinical professor, M.D., M.Sc., F.R.C.P.C.
CHU de Quebec-Universite Laval
Eligibility Criteria
Inclusion Criteria
- •Biopsy proven Prostate adenocarcinoma
- •Stage T1c, T2 (Annex 2)
- •Stage Nx or N0
- •Stage Mx or M0
- •PSA \< 20ng/ml
- •Gleason Score 6 or 7
- •Having the ability to sing a written consent
Exclusion Criteria
- •Age \< 18ans
- •Clinical Stage T3 or T4
- •PSA \> 20
- •Gleason Score 8 to 10
- •IPSS Score \> 20 alpha-blocking medication.
- •Prior pelvic radiotherapy.
- •History of active collagenosis (Lupus, Sclerodermia, Dermatomyosis)
- •Past history of Inflammatory Bowell Disease
- •Bilateral hip prosthesis
Outcomes
Primary Outcomes
urinary toxicity analysis (IPSS)
Time Frame: at 5 years
median IPSS scores will be reported post-therapy and compare between arms at 5 years post-therapy
GU toxicity analysis (CTCAE)
Time Frame: at 5 years post-therapy
quantitatively evaluated using CTCAE (v5) and compare between arms
GI toxicity analysis (CTCAE)
Time Frame: at 5 years post-therapy
quantitatively evaluated using CTCAE (v5) and compare between arms
sexual function analysis (SHIM)
Time Frame: at 5 years
median SHIM scores will be reported post-therapy and compare between arms at 5 years post-treatment
quality of life questionnaires analysis (EPIC26)
Time Frame: at 5 years
median EPIC26 scores will be reported post-therapy and compare between arms at 5 years post-treatment
Secondary Outcomes
- Clinical outcomes(at 10 years)