A randomised clinical trial on the efficacy of intravenous N-acetylcysteine compared to oral N-acetylcysteine and oral methionine in reducing liver cell injury in paracetamol (acetaminophen) poisoning

South Asian Clinical Toxicology Research Collaboration (SACTRC)0 个研究点开始时间: 待定最近更新: 2024年8月20日

适应症

试验速览

暂无简介。

•1. Age 16 years and above
•2. All patients who have taken a paracetamol overdose (>200mg/kg) where the physician determines an antidote is to be administered

•1. Patients presenting 24 hours or more after poisoning.
•2. Patients who have already received an antidote (possible in other hospitals prior to transfer).
•3. Patients who have received charcoal (which would interfere with oral antidotes).
•4. Patients under the age of 16.
•5. Patients who are institutionalized for any mental health condition.
•6. Patients with known cognitive impairment (e.g. dementia).
•7. Patients with unrelated life threatening illness (e.g. terminal cancer).
•8. Patients who are pregnant.
•9. Patients who have had a paracetamol overdose in the previous 4 weeks or have taken a significant dose of any other toxic substance in addition to paracetamol.
•10. Patients who are on warfarin.

发起方

South Asian Clinical Toxicology Research Collaboration (SACTRC)